Assay Detail
Binding
CHEMBL3705295
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Fluorescence Polarization Competition Assay: An autophosphorylation, fluroescence polarization competition immunoassay was used to determine the potency for c-fms inhibition.
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Macrophage colony-stimulating factor 1 receptor (CHEMBL5570) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
4-Cyano-1H-imidazole-2-carboxylic acid [2-cyclohex-1-enyl-4-(2,6-dioxo-piperidin-4-yl)-phenyl]-amide; tyrosine kinase inhibitor; autoimmune diseases, antiinflammatory, anticarcinogenic agent
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 8.73 | 9.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3674575 | — | — | 1 | 9.39 |
| CHEMBL3674563 | — | — | 1 | 9.38 |
| CHEMBL3639734 | — | — | 1 | 9.37 |
| CHEMBL3674560 | — | — | 1 | 9.33 |
| CHEMBL3674558 | — | — | 1 | 9.19 |
| CHEMBL3674579 | — | — | 1 | 9.18 |
| CHEMBL3905759 | — | — | 1 | 9.18 |
| CHEMBL3674559 | — | — | 1 | 9.14 |
| CHEMBL3919523 | — | — | 1 | 9.14 |
| CHEMBL3986577 | — | — | 1 | 9.09 |
| CHEMBL3956660 | — | — | 1 | 9.07 |
| CHEMBL3674569 | — | — | 1 | 8.96 |
| CHEMBL3963729 | — | — | 1 | 8.96 |
| CHEMBL3674571 | — | — | 1 | 8.85 |
| CHEMBL3908207 | — | — | 1 | 8.74 |
| CHEMBL3674562 | — | — | 1 | 8.70 |
| CHEMBL3674577 | — | — | 1 | 8.70 |
| CHEMBL3674561 | — | — | 1 | 8.57 |
| CHEMBL3674570 | EDICOTINIB | 2.0 | 1 | 8.54 |
| CHEMBL3968152 | — | — | 1 | 8.54 |
| CHEMBL3674565 | — | — | 1 | 8.46 |
| CHEMBL3956906 | — | — | 1 | 8.34 |
| CHEMBL3674578 | — | — | 1 | 8.15 |
| CHEMBL3674576 | — | — | 1 | 8.05 |
| CHEMBL3674581 | — | — | 1 | 7.85 |
| CHEMBL3674580 | — | — | 1 | 7.80 |
| CHEMBL3674582 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3674575 | — | IC50 | = | 0.41 | nM | 9.39 |
| CHEMBL3674563 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL3639734 | — | IC50 | = | 0.43 | nM | 9.37 |
| CHEMBL3674560 | — | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL3674558 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL3674579 | — | IC50 | = | 0.66 | nM | 9.18 |
| CHEMBL3905759 | — | IC50 | = | 0.66 | nM | 9.18 |
| CHEMBL3674559 | — | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL3919523 | — | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL3986577 | — | IC50 | = | 0.81 | nM | 9.09 |
| CHEMBL3956660 | — | IC50 | = | 0.86 | nM | 9.07 |
| CHEMBL3674569 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3963729 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3674571 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3908207 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL3674562 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3674577 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3674561 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL3674570 | EDICOTINIB | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL3968152 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL3674565 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL3956906 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL3674578 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL3674576 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL3674581 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3674580 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3674582 | — | IC50 | = | 99.0 | nM | 7.00 |