Assay Detail
Binding
CHEMBL3705546
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tyrosine Kinase Assay: Kinase assay using IGF1-receptor.
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Insulin-like growth factor 1 receptor (CHEMBL1957) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pyrrolotriazine kinase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 7.37 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3639546 | — | — | 1 | 9.00 |
| CHEMBL3655752 | — | — | 1 | 9.00 |
| CHEMBL3655756 | — | — | 1 | 9.00 |
| CHEMBL3655750 | — | — | 1 | 9.00 |
| CHEMBL3655747 | — | — | 1 | 8.70 |
| CHEMBL575447 | — | — | 1 | 8.70 |
| CHEMBL3655759 | — | — | 1 | 8.70 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 8.70 |
| CHEMBL3655757 | — | — | 1 | 8.70 |
| CHEMBL3655754 | — | — | 1 | 8.70 |
| CHEMBL3655753 | — | — | 1 | 8.70 |
| CHEMBL3655761 | — | — | 1 | 8.52 |
| CHEMBL3655755 | — | — | 1 | 8.52 |
| CHEMBL577385 | — | — | 1 | 8.40 |
| CHEMBL3655751 | — | — | 1 | 8.30 |
| CHEMBL3655758 | — | — | 1 | 8.30 |
| CHEMBL3655749 | — | — | 1 | 8.30 |
| CHEMBL3655739 | — | — | 1 | 8.15 |
| CHEMBL3655760 | — | — | 1 | 7.85 |
| CHEMBL3655738 | — | — | 1 | 7.80 |
| CHEMBL3655744 | — | — | 1 | 7.68 |
| CHEMBL3655745 | — | — | 1 | 7.55 |
| CHEMBL3655742 | — | — | 1 | 7.47 |
| CHEMBL576179 | — | — | 1 | 7.37 |
| CHEMBL3655737 | — | — | 1 | 7.24 |
| CHEMBL3655728 | — | — | 1 | 7.14 |
| CHEMBL3655726 | — | — | 1 | 7.01 |
| CHEMBL3655725 | — | — | 1 | 6.91 |
| CHEMBL3655724 | — | — | 1 | 6.77 |
| CHEMBL3655731 | — | — | 1 | 6.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3639546 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3655750 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3655756 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3655752 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3655747 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL575447 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3655759 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3655757 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3655754 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3655753 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3655761 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3655755 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL577385 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3655749 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3655751 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3655758 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3655739 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3655760 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3655738 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3655744 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3655745 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL3655742 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL576179 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL3655737 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL3655728 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL3655726 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL3655725 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL3655724 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3655731 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL3655746 | — | IC50 | = | 232.0 | nM | 6.63 |
| CHEMBL3655727 | — | IC50 | = | 361.0 | nM | 6.44 |
| CHEMBL3655740 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL3655735 | — | IC50 | = | 428.0 | nM | 6.37 |
| CHEMBL3655736 | — | IC50 | = | 462.0 | nM | 6.33 |
| CHEMBL3655732 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL3655743 | — | IC50 | = | 912.0 | nM | 6.04 |
| CHEMBL3655730 | — | IC50 | = | 1522.0 | nM | 5.82 |
| CHEMBL3655723 | — | IC50 | = | 1757.0 | nM | 5.75 |
| CHEMBL3655748 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL3655734 | — | IC50 | = | 2507.0 | nM | 5.60 |
| CHEMBL3655741 | — | IC50 | = | 2724.0 | nM | 5.57 |
| CHEMBL3655729 | — | IC50 | = | 2840.0 | nM | 5.55 |
| CHEMBL3655722 | — | IC50 | = | 3166.0 | nM | 5.50 |
| CHEMBL3655733 | — | IC50 | = | 17740.0 | nM | 4.75 |