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Assay Detail

CHEMBL3707592

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding Assay: Binding assay of certain compounds of this invention to the opioid receptor was determine using radioligand binding assay (screening and dose-displacement).
ChEMBL ↗
79
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Mu-type opioid receptor (CHEMBL233) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Buprenophine analogs
(2013)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 79 8.35 10.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3919397 — — 3 10.40
CHEMBL3908275 — — 3 10.30
CHEMBL3893577 — — 3 10.30
CHEMBL3944046 — — 2 10.15
CHEMBL3911769 — — 2 10.10
CHEMBL3952829 — — 2 10.00
CHEMBL3907149 — — 3 9.92
CHEMBL3916122 — — 3 9.92
CHEMBL3951177 — — 2 9.82
CHEMBL3912511 — — 3 9.82
CHEMBL3901699 — — 3 9.82
CHEMBL3892737 — — 2 9.82
CHEMBL3664525 — — 2 9.77
CHEMBL3664526 — — 2 9.68
CHEMBL3923372 — — 3 9.64
CHEMBL3948231 — — 3 9.46
CHEMBL3904663 — — 3 9.40
CHEMBL3947184 — — 3 9.37
CHEMBL3982823 — — 2 9.28
CHEMBL3915488 — — 2 9.13
CHEMBL4107573 — — 3 8.89
CHEMBL3954498 — — 3 8.72
CHEMBL3959791 — — 2 8.64
CHEMBL3948400 — — 3 8.59
CHEMBL3911529 — — 3 8.57
CHEMBL3955920 — — 3 8.53
CHEMBL3900482 — — 2 8.45
CHEMBL3946351 — — 2 8.36
CHEMBL3664540 — — 3 8.23
CHEMBL3664541 — — 2 8.19

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3919397 — Ki = 0.04 nM 10.40
CHEMBL3908275 — Ki = 0.05 nM 10.30
CHEMBL3893577 — Ki = 0.05 nM 10.30
CHEMBL3944046 — Ki = 0.07 nM 10.15
CHEMBL3911769 — Ki = 0.08 nM 10.10
CHEMBL3952829 — Ki = 0.1 nM 10.00
CHEMBL3907149 — Ki = 0.12 nM 9.92
CHEMBL3916122 — Ki = 0.12 nM 9.92
CHEMBL3901699 — Ki = 0.15 nM 9.82
CHEMBL3912511 — Ki = 0.15 nM 9.82
CHEMBL3951177 — Ki = 0.15 nM 9.82
CHEMBL3892737 — Ki = 0.15 nM 9.82
CHEMBL3664525 — Ki = 0.17 nM 9.77
CHEMBL3664526 — Ki = 0.21 nM 9.68
CHEMBL3923372 — Ki = 0.23 nM 9.64
CHEMBL3948231 — Ki = 0.35 nM 9.46
CHEMBL3904663 — Ki = 0.4 nM 9.40
CHEMBL3947184 — Ki = 0.43 nM 9.37
CHEMBL3982823 — Ki = 0.53 nM 9.28
CHEMBL3911769 — Ki = 0.59 nM 9.23
CHEMBL3908275 — Ki = 0.69 nM 9.16
CHEMBL3915488 — Ki = 0.74 nM 9.13
CHEMBL3923372 — Ki = 1.0 nM 9.00
CHEMBL3664525 — Ki = 1.12 nM 8.95
CHEMBL3892737 — Ki = 1.2 nM 8.92
CHEMBL3919397 — Ki = 1.22 nM 8.91
CHEMBL4107573 — Ki = 1.3 nM 8.89
CHEMBL3907149 — Ki = 1.47 nM 8.83
CHEMBL3944046 — Ki = 1.55 nM 8.81
CHEMBL3912511 — Ki = 1.6 nM 8.80
CHEMBL3952829 — Ki = 1.76 nM 8.75
CHEMBL3915488 — Ki = 1.87 nM 8.73
CHEMBL3954498 — Ki = 1.91 nM 8.72
CHEMBL3916122 — Ki = 2.0 nM 8.70
CHEMBL3904663 — Ki = 2.2 nM 8.66
CHEMBL3959791 — Ki = 2.3 nM 8.64
CHEMBL3893577 — Ki = 2.58 nM 8.59
CHEMBL3948400 — Ki = 2.6 nM 8.59
CHEMBL3911529 — Ki = 2.7 nM 8.57
CHEMBL3955920 — Ki = 2.95 nM 8.53
CHEMBL3900482 — Ki = 3.58 nM 8.45
CHEMBL3982823 — Ki = 4.35 nM 8.36
CHEMBL3946351 — Ki = 4.4 nM 8.36
CHEMBL3948231 — Ki = 4.38 nM 8.36
CHEMBL3946351 — Ki = 5.71 nM 8.24
CHEMBL3664540 — Ki = 5.9 nM 8.23
CHEMBL3664526 — Ki = 6.37 nM 8.20
CHEMBL3664541 — Ki = 6.5 nM 8.19
CHEMBL3900482 — Ki = 7.99 nM 8.10
CHEMBL3916122 — Ki = 9.2 nM 8.04