Assay Detail
Binding
CHEMBL3707672
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Radioligand Binding Assay: Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyridyl piperidine orexin receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 8.82 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3655673 | — | — | 1 | 10.10 |
| CHEMBL3235249 | — | — | 1 | 9.62 |
| CHEMBL3655670 | — | — | 1 | 9.62 |
| CHEMBL2107822 | FILOREXANT | 2.0 | 1 | 9.51 |
| CHEMBL3655674 | — | — | 1 | 9.46 |
| CHEMBL3655671 | — | — | 1 | 9.43 |
| CHEMBL3655676 | — | — | 1 | 9.32 |
| CHEMBL3655672 | — | — | 1 | 9.30 |
| CHEMBL3655675 | — | — | 1 | 9.28 |
| CHEMBL3655664 | — | — | 1 | 9.27 |
| CHEMBL3655679 | — | — | 1 | 9.17 |
| CHEMBL3655680 | — | — | 1 | 9.17 |
| CHEMBL3655665 | — | — | 1 | 9.17 |
| CHEMBL3655681 | — | — | 1 | 8.82 |
| CHEMBL3655667 | — | — | 1 | 8.77 |
| CHEMBL3655677 | — | — | 1 | 8.77 |
| CHEMBL3655682 | — | — | 1 | 8.72 |
| CHEMBL3655669 | — | — | 1 | 8.70 |
| CHEMBL3655683 | — | — | 1 | 8.42 |
| CHEMBL3655678 | — | — | 1 | 8.00 |
| CHEMBL3655684 | — | — | 1 | 7.66 |
| CHEMBL3655663 | — | — | 1 | 7.54 |
| CHEMBL3655668 | — | — | 1 | 7.43 |
| CHEMBL3655666 | — | — | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3655673 | — | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL3235249 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL3655670 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL2107822 | FILOREXANT | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL3655674 | — | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL3655671 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL3655676 | — | Ki | = | 0.48 | nM | 9.32 |
| CHEMBL3655672 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL3655675 | — | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL3655664 | — | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL3655679 | — | Ki | = | 0.67 | nM | 9.17 |
| CHEMBL3655680 | — | Ki | = | 0.68 | nM | 9.17 |
| CHEMBL3655665 | — | Ki | = | 0.67 | nM | 9.17 |
| CHEMBL3655681 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL3655667 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL3655677 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL3655682 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL3655669 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL3655683 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL3655678 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL3655684 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL3655663 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL3655668 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL3655666 | — | Ki | = | 410.0 | nM | 6.39 |