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Assay Detail

CHEMBL3720809

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antagonist activity against GPR84 in human buffy coat neutrophils assessed as reduction in neutrophils migration towards embelin pre-incubated for 30 mins and measured after 1 hr by ATPlite luminescence ATP detection assay
ChEMBL ↗
58
Total Activities
58
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

G-protein coupled receptor 84 (CHEMBL3714079) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Dihydropyrimidinoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders
(2015)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 58 10.24 11.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3716889 — — 1 11.00
CHEMBL3716446 — — 1 11.00
CHEMBL3717201 — — 1 11.00
CHEMBL3716184 — — 1 11.00
CHEMBL3717086 — — 1 11.00
CHEMBL3717755 — — 1 11.00
CHEMBL3714986 — — 1 11.00
CHEMBL3717924 — — 1 11.00
CHEMBL3715918 — — 1 11.00
CHEMBL3717790 — — 1 11.00
CHEMBL3715679 — — 1 11.00
CHEMBL3718719 — — 1 11.00
CHEMBL3716280 — — 1 11.00
CHEMBL3716527 — — 1 11.00
CHEMBL3718174 — — 1 11.00
CHEMBL3718818 — — 1 11.00
CHEMBL3716024 — — 1 11.00
CHEMBL3716561 — — 1 11.00
CHEMBL3718720 — — 1 11.00
CHEMBL3716365 GLPG-1205 2.0 1 11.00
CHEMBL3715055 — — 1 11.00
CHEMBL3716784 — — 1 11.00
CHEMBL3715907 — — 1 11.00
CHEMBL3715064 — — 1 11.00
CHEMBL3717363 — — 1 11.00
CHEMBL3717416 — — 1 11.00
CHEMBL3715656 — — 1 11.00
CHEMBL3717641 — — 1 11.00
CHEMBL3714875 — — 1 11.00
CHEMBL3717453 — — 1 11.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3717158 — IC50 = 0.01 nM 11.00
CHEMBL3714986 — IC50 = 0.01 nM 11.00
CHEMBL3717755 — IC50 = 0.01 nM 11.00
CHEMBL3717086 — IC50 = 0.01 nM 11.00
CHEMBL3716184 — IC50 = 0.01 nM 11.00
CHEMBL3717201 — IC50 = 0.01 nM 11.00
CHEMBL3716446 — IC50 = 0.01 nM 11.00
CHEMBL3718280 — IC50 = 0.01 nM 11.00
CHEMBL3719092 — IC50 = 0.01 nM 11.00
CHEMBL3717390 — IC50 = 0.01 nM 11.00
CHEMBL3715514 — IC50 = 0.01 nM 11.00
CHEMBL3715322 — IC50 = 0.01 nM 11.00
CHEMBL3717453 — IC50 = 0.01 nM 11.00
CHEMBL3715923 — IC50 = 0.01 nM 11.00
CHEMBL3719364 — IC50 = 0.01 nM 11.00
CHEMBL3719258 — IC50 = 0.01 nM 11.00
CHEMBL3718080 — IC50 = 0.01 nM 11.00
CHEMBL3717251 — IC50 = 0.01 nM 11.00
CHEMBL3716728 — IC50 = 0.01 nM 11.00
CHEMBL3717905 — IC50 = 0.01 nM 11.00
CHEMBL3715443 — IC50 = 0.01 nM 11.00
CHEMBL3718331 — IC50 = 0.01 nM 11.00
CHEMBL3719374 — IC50 = 0.01 nM 11.00
CHEMBL3714904 — IC50 = 0.01 nM 11.00
CHEMBL3715918 — IC50 = 0.01 nM 11.00
CHEMBL3718818 — IC50 = 0.01 nM 11.00
CHEMBL3714875 — IC50 = 0.01 nM 11.00
CHEMBL3717641 — IC50 = 0.01 nM 11.00
CHEMBL3715656 — IC50 = 0.01 nM 11.00
CHEMBL3717416 — IC50 = 0.01 nM 11.00
CHEMBL3717363 — IC50 = 0.01 nM 11.00
CHEMBL3715064 — IC50 = 0.01 nM 11.00
CHEMBL3715907 — IC50 = 0.01 nM 11.00
CHEMBL3716784 — IC50 = 0.01 nM 11.00
CHEMBL3715055 — IC50 = 0.01 nM 11.00
CHEMBL3716365 GLPG-1205 IC50 = 0.01 nM 11.00
CHEMBL3718720 — IC50 = 0.01 nM 11.00
CHEMBL3716561 — IC50 = 0.01 nM 11.00
CHEMBL3716024 — IC50 = 0.01 nM 11.00
CHEMBL3716889 — IC50 = 0.01 nM 11.00
CHEMBL3718174 — IC50 = 0.01 nM 11.00
CHEMBL3716527 — IC50 = 0.01 nM 11.00
CHEMBL3716280 — IC50 = 0.01 nM 11.00
CHEMBL3718719 — IC50 = 0.01 nM 11.00
CHEMBL3715679 — IC50 = 0.01 nM 11.00
CHEMBL3717790 — IC50 = 0.01 nM 11.00
CHEMBL3717924 — IC50 = 0.01 nM 11.00
CHEMBL3718012 — IC50 = 101.0 nM 7.00
CHEMBL3715095 — IC50 = 101.0 nM 7.00
CHEMBL3716157 — IC50 = 101.0 nM 7.00