Compound Detail
CHEMBL3719364
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL3719364 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KSGKMLVYIUJQMZ-UHFFFAOYSA-N |
1
Targets
5
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
421.4
MW (Da)
2.23
ALogP
8
HBA
0
HBD
84.7
PSA (Ų)
0.60
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 11.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| G-protein coupled receptor 84 CHEMBL3714079 | IC50 | 11.0 | 8.26 | 0.0 | 5 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| G-protein coupled receptor 84 | IC50 | = | 0.01 | nM | 11.0 | Antagonist activity against GPR84 (unknown origin) expressed in cell membranes i... | - |
| G-protein coupled receptor 84 | IC50 | = | 0.01 | nM | 11.0 | Antagonist activity against GPR84 in human buffy coat neutrophils assessed as re... | - |
| G-protein coupled receptor 84 | IC50 | = | 260.0 | nM | 6.58 | Antagonist activity at human GPR84 expressed in CHO-K1 cells assessed as reducti... | 33267584 |
| G-protein coupled receptor 84 | IC50 | = | 260.0 | nM | 6.58 | Antagonist activity at human GPR84 expressed in CHO-K1 cells assessed as reducti... | 35195005 |
| G-protein coupled receptor 84 | IC50 | = | 716.0 | nM | 6.14 | Antagonist activity at human GPR84 expressed in HEK293 cells co-expressing Galph... | 35195005 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35195005 | 10.1021/acs.jmedchem.1c01813 | G-protein coupled receptor 84 | 2 |
| 33267584 | 10.1021/acs.jmedchem.0c01378 | G-protein coupled receptor 84 | 1 |
Data from ChEMBL 36 via Core Engine