Assay Detail
Functional
CHEMBL3720936
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human T47D cells assessed as reduction in cell growth incubated for 72 hrs by CCK8 assay
63
Total Activities
62
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Imidazopyridine derivatives and pbk inhibitors containing the same
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 63 | 5.54 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3718783 | — | — | 1 | 6.92 |
| CHEMBL3717297 | — | — | 1 | 6.72 |
| CHEMBL3717063 | — | — | 1 | 6.50 |
| CHEMBL3715388 | — | — | 1 | 6.50 |
| CHEMBL3717295 | — | — | 1 | 6.38 |
| CHEMBL3716044 | — | — | 1 | 6.38 |
| CHEMBL3715412 | — | — | 1 | 6.38 |
| CHEMBL3716639 | — | — | 1 | 6.35 |
| CHEMBL3718439 | — | — | 1 | 6.21 |
| CHEMBL3717191 | — | — | 1 | 6.14 |
| CHEMBL3716635 | — | — | 1 | 6.14 |
| CHEMBL3718268 | — | — | 1 | 6.12 |
| CHEMBL3719067 | — | — | 1 | 6.10 |
| CHEMBL3718368 | — | — | 1 | 6.08 |
| CHEMBL3716544 | — | — | 1 | 6.06 |
| CHEMBL3718407 | — | — | 1 | 6.03 |
| CHEMBL3715825 | — | — | 1 | 6.03 |
| CHEMBL3718039 | — | — | 1 | 6.02 |
| CHEMBL3715508 | — | — | 1 | 6.00 |
| CHEMBL3715533 | — | — | 1 | 5.96 |
| CHEMBL3715360 | — | — | 1 | 5.82 |
| CHEMBL3715032 | — | — | 1 | 5.80 |
| CHEMBL3717470 | — | — | 2 | 5.68 |
| CHEMBL3718105 | — | — | 1 | 5.68 |
| CHEMBL3717174 | — | — | 1 | 5.62 |
| CHEMBL3717234 | — | — | 1 | 5.62 |
| CHEMBL3717532 | — | — | 1 | 5.60 |
| CHEMBL3716396 | — | — | 1 | 5.60 |
| CHEMBL3715259 | — | — | 1 | 5.58 |
| CHEMBL3719168 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3718783 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3717297 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3715388 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3717063 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3717295 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL3716044 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL3715412 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL3716639 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL3718439 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL3716635 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL3717191 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL3718268 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL3719067 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL3718368 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL3716544 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL3718407 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL3715825 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL3718039 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL3715508 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3715533 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3715360 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3715032 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3718105 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3717470 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3717234 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3717174 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3717532 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3716396 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3715259 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3719168 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3718730 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL3717470 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL3714773 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3718636 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3718019 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL3716274 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL3718661 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL3717030 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL3716048 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL3717765 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL3715919 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL3716727 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL3716771 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL3716309 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL3716936 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL3717200 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL3715494 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL3716839 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3715121 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3716143 | — | IC50 | = | 14000.0 | nM | 4.85 |