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Assay Detail

CHEMBL3734547

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of PHA/TPA-induced IL2 release in human Jurkat T cells preincubated for 10 mins followed by PHA/TPA stimulation measured after 20 mins by ELISA
ChEMBL ↗
84
Total Activities
84
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type Jurkat
Confidence 1 — Organism
Curated By Autocuration

Target

Jurkat (CHEMBL397) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Compounds that modulate intracellular calcium
(2012)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 84 7.30 7.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3733059 — — 1 7.30
CHEMBL3730952 — — 1 7.30
CHEMBL3732620 — — 1 7.30
CHEMBL3731030 — — 1 7.30
CHEMBL3730254 — — 1 -
CHEMBL3728875 — — 1 -
CHEMBL3729158 — — 1 -
CHEMBL3728450 — — 1 -
CHEMBL3733254 — — 1 -
CHEMBL3732450 — — 1 -
CHEMBL3729221 — — 1 -
CHEMBL3729109 — — 1 -
CHEMBL3729771 — — 1 -
CHEMBL3728704 — — 1 -
CHEMBL3730740 — — 1 -
CHEMBL3729101 — — 1 -
CHEMBL3729841 — — 1 -
CHEMBL3732677 — — 1 -
CHEMBL3728713 — — 1 -
CHEMBL3730610 — — 1 -
CHEMBL3730176 — — 1 -
CHEMBL3728931 — — 1 -
CHEMBL3733040 — — 1 -
CHEMBL3730009 — — 1 -
CHEMBL3727734 — — 1 -
CHEMBL3733237 — — 1 -
CHEMBL3731765 — — 1 -
CHEMBL3732110 — — 1 -
CHEMBL3732779 — — 1 -
CHEMBL3729234 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3733059 — IC50 = 50.0 nM 7.30
CHEMBL3730952 — IC50 = 50.0 nM 7.30
CHEMBL3732620 — IC50 = 50.0 nM 7.30
CHEMBL3731030 — IC50 = 50.0 nM 7.30
CHEMBL3729101 — IC50 < 50.0 nM -
CHEMBL3731250 — IC50 - — -
CHEMBL3729841 — IC50 < 50.0 nM -
CHEMBL3728875 — IC50 < 50.0 nM -
CHEMBL3727938 — IC50 < 50.0 nM -
CHEMBL3732114 — IC50 - — -
CHEMBL3729900 — IC50 < 50.0 nM -
CHEMBL3728855 — IC50 < 50.0 nM -
CHEMBL3731651 — IC50 < 50.0 nM -
CHEMBL3729551 — IC50 - — -
CHEMBL3733355 — IC50 < 50.0 nM -
CHEMBL3727989 — IC50 - — -
CHEMBL3728468 — IC50 - — -
CHEMBL3727611 — IC50 - — -
CHEMBL3731488 — IC50 - — -
CHEMBL3728218 — IC50 - — -
CHEMBL3728323 — IC50 < 50.0 nM -
CHEMBL3730598 — IC50 < 50.0 nM -
CHEMBL3727872 — IC50 - — -
CHEMBL3728825 — IC50 - — -
CHEMBL3732563 — IC50 - — -
CHEMBL3728232 — IC50 - — -
CHEMBL3729488 — IC50 - — -
CHEMBL3728713 — IC50 - — -
CHEMBL3729234 — IC50 - — -
CHEMBL3732779 — IC50 - — -
CHEMBL3732110 — IC50 - — -
CHEMBL3731765 — IC50 < 50.0 nM -
CHEMBL3733237 — IC50 - — -
CHEMBL3727734 — IC50 - — -
CHEMBL3730009 — IC50 < 50.0 nM -
CHEMBL3733040 — IC50 < 50.0 nM -
CHEMBL3728931 — IC50 - — -
CHEMBL3730176 — IC50 - — -
CHEMBL3730610 — IC50 - — -
CHEMBL3730740 — IC50 < 50.0 nM -
CHEMBL3732677 — IC50 - — -
CHEMBL3730254 — IC50 - — -
CHEMBL3729158 — IC50 < 50.0 nM -
CHEMBL3728450 — IC50 < 50.0 nM -
CHEMBL3733254 — IC50 < 50.0 nM -
CHEMBL3732450 — IC50 < 50.0 nM -
CHEMBL3729221 — IC50 - — -
CHEMBL3729109 — IC50 < 50.0 nM -
CHEMBL3729771 — IC50 < 50.0 nM -
CHEMBL3728704 — IC50 < 50.0 nM -