Assay Detail
Functional
CHEMBL3737250
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Agonist activity at rat NK3 receptor expressed in CHO cells assessed as calcium influx relative to 100 nM senktide
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structureactivity relationship study on senktide for development of novel potent neurokinin-3 receptor selective agonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 10.77 | 10.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3734811 | — | — | 1 | 10.89 |
| CHEMBL106124 | SENKTIDE | — | 1 | 10.64 |
| CHEMBL3736361 | — | — | 1 | - |
| CHEMBL3736089 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3734811 | — | EC50 | = | 0.013 | nM | 10.89 |
| CHEMBL106124 | SENKTIDE | EC50 | = | 0.023 | nM | 10.64 |
| CHEMBL3736361 | — | EC50 | = | 0.0099 | nM | - |
| CHEMBL3736089 | — | EC50 | = | 0.0072 | nM | - |