Assay Detail
Functional
CHEMBL3743797
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Antiviral activity against wild type Chikungunya virus IMT infected in HEK293T cells assessed as inhibition of infectivity measured at 24 hrs postinfection by FITC/DAPI staining based array scan VTI HCS reader analysis
22
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Chikungunya virus |
| Cell Type | HEK-293T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Trisubstituted Thieno[3,2-b]pyrrole 5-Carboxamides as Potent Inhibitors of Alphaviruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.17 | 5.71 |
| Inhibition | 11 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3741103 | — | — | 2 | 5.71 |
| CHEMBL3740865 | — | — | 2 | 5.62 |
| CHEMBL3739973 | — | — | 2 | 5.51 |
| CHEMBL3741166 | — | — | 2 | 5.49 |
| CHEMBL3741047 | — | — | 2 | 5.25 |
| CHEMBL3741868 | — | — | 2 | 5.18 |
| CHEMBL3740343 | — | — | 2 | 5.08 |
| CHEMBL3740995 | — | — | 2 | 4.87 |
| CHEMBL3741851 | — | — | 2 | 4.85 |
| CHEMBL1643 | RIBAVIRIN | 4.0 | 2 | 4.70 |
| CHEMBL3742296 | — | — | 2 | 4.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3741103 | — | EC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL3740865 | — | EC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL3739973 | — | EC50 | = | 3080.0 | nM | 5.51 |
| CHEMBL3741166 | — | EC50 | = | 3270.0 | nM | 5.49 |
| CHEMBL3741047 | — | EC50 | = | 5590.0 | nM | 5.25 |
| CHEMBL3741868 | — | EC50 | = | 6550.0 | nM | 5.18 |
| CHEMBL3740343 | — | EC50 | = | 8230.0 | nM | 5.08 |
| CHEMBL3740995 | — | EC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL3741851 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL1643 | RIBAVIRIN | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3742296 | — | EC50 | = | 25500.0 | nM | 4.59 |
| CHEMBL3741868 | — | Inhibition | - | % | - | |
| CHEMBL3741047 | — | Inhibition | - | % | - | |
| CHEMBL3742296 | — | Inhibition | - | % | - | |
| CHEMBL3741103 | — | Inhibition | - | % | - | |
| CHEMBL3740995 | — | Inhibition | - | % | - | |
| CHEMBL3740865 | — | Inhibition | - | % | - | |
| CHEMBL3741166 | — | Inhibition | - | % | - | |
| CHEMBL3739973 | — | Inhibition | - | % | - | |
| CHEMBL3740343 | — | Inhibition | - | % | - | |
| CHEMBL3741851 | — | Inhibition | - | % | - | |
| CHEMBL1643 | RIBAVIRIN | Inhibition | - | % | - |