Assay Detail
Binding
CHEMBL3744548
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Displacement of [3H]spiperone from dopamine D2 receptor in rat striatum
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of amide, sulfonamide and urea benzisoxazole derivatives as potential atypical antipsychotics
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 6.56 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 8.55 |
| CHEMBL3741292 | — | — | 1 | 8.06 |
| CHEMBL3740256 | — | — | 1 | 7.49 |
| CHEMBL3740925 | — | — | 1 | 7.07 |
| CHEMBL3740807 | — | — | 1 | 7.06 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.88 |
| CHEMBL3742070 | — | — | 1 | 6.75 |
| CHEMBL3742368 | — | — | 1 | 6.72 |
| CHEMBL3741140 | — | — | 1 | 6.71 |
| CHEMBL3742391 | — | — | 1 | 6.68 |
| CHEMBL3739523 | — | — | 1 | 6.23 |
| CHEMBL3740759 | — | — | 1 | 6.12 |
| CHEMBL3740680 | — | — | 1 | 5.96 |
| CHEMBL3740636 | — | — | 1 | 5.92 |
| CHEMBL3741924 | — | — | 1 | 5.90 |
| CHEMBL3741596 | — | — | 1 | 5.89 |
| CHEMBL3739935 | — | — | 1 | 5.89 |
| CHEMBL3742136 | — | — | 1 | 5.89 |
| CHEMBL3740811 | — | — | 1 | 5.86 |
| CHEMBL3741553 | — | — | 1 | 5.60 |
| CHEMBL3739805 | — | — | 1 | - |
| CHEMBL3741925 | — | — | 1 | - |
| CHEMBL3742362 | — | — | 1 | - |
| CHEMBL3741933 | — | — | 1 | - |
| CHEMBL3741516 | — | — | 1 | - |
| CHEMBL3741698 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85 | RISPERIDONE | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL3741292 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL3740256 | — | Ki | = | 32.6 | nM | 7.49 |
| CHEMBL3740925 | — | Ki | = | 85.6 | nM | 7.07 |
| CHEMBL3740807 | — | Ki | = | 86.8 | nM | 7.06 |
| CHEMBL42 | CLOZAPINE | Ki | = | 130.7 | nM | 6.88 |
| CHEMBL3742070 | — | Ki | = | 178.1 | nM | 6.75 |
| CHEMBL3742368 | — | Ki | = | 190.4 | nM | 6.72 |
| CHEMBL3741140 | — | Ki | = | 194.6 | nM | 6.71 |
| CHEMBL3742391 | — | Ki | = | 210.9 | nM | 6.68 |
| CHEMBL3739523 | — | Ki | = | 589.7 | nM | 6.23 |
| CHEMBL3740759 | — | Ki | = | 758.8 | nM | 6.12 |
| CHEMBL3740680 | — | Ki | = | 1099.1 | nM | 5.96 |
| CHEMBL3740636 | — | Ki | = | 1191.1 | nM | 5.92 |
| CHEMBL3741924 | — | Ki | = | 1268.2 | nM | 5.90 |
| CHEMBL3741596 | — | Ki | = | 1273.8 | nM | 5.89 |
| CHEMBL3739935 | — | Ki | = | 1287.1 | nM | 5.89 |
| CHEMBL3742136 | — | Ki | = | 1290.8 | nM | 5.89 |
| CHEMBL3740811 | — | Ki | = | 1382.5 | nM | 5.86 |
| CHEMBL3741553 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL3739805 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3741925 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3742362 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3741933 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3741516 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3741698 | — | Ki | > | 10000.0 | nM | - |