Assay Detail
Binding
CHEMBL3744550
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Displacement of [3H]ketanserin from 5HT2A receptor in rat brain cortex
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of amide, sulfonamide and urea benzisoxazole derivatives as potential atypical antipsychotics
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 7.15 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 9.60 |
| CHEMBL3741292 | — | — | 1 | 9.10 |
| CHEMBL3740925 | — | — | 1 | 8.17 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.89 |
| CHEMBL3740256 | — | — | 1 | 7.80 |
| CHEMBL3740807 | — | — | 1 | 7.72 |
| CHEMBL3742070 | — | — | 1 | 7.57 |
| CHEMBL3739523 | — | — | 1 | 7.57 |
| CHEMBL3740680 | — | — | 1 | 7.52 |
| CHEMBL3740811 | — | — | 1 | 7.49 |
| CHEMBL3741698 | — | — | 1 | 7.17 |
| CHEMBL3741140 | — | — | 1 | 7.14 |
| CHEMBL3742368 | — | — | 1 | 6.95 |
| CHEMBL3741596 | — | — | 1 | 6.94 |
| CHEMBL3740636 | — | — | 1 | 6.92 |
| CHEMBL3740759 | — | — | 1 | 6.87 |
| CHEMBL3742362 | — | — | 1 | 6.67 |
| CHEMBL3741924 | — | — | 1 | 6.58 |
| CHEMBL3741933 | — | — | 1 | 6.51 |
| CHEMBL3742391 | — | — | 1 | 6.43 |
| CHEMBL3742136 | — | — | 1 | 6.34 |
| CHEMBL3741925 | — | — | 1 | 6.25 |
| CHEMBL3739805 | — | — | 1 | 5.96 |
| CHEMBL3739935 | — | — | 1 | 5.82 |
| CHEMBL3741516 | — | — | 1 | 5.67 |
| CHEMBL3741553 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85 | RISPERIDONE | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL3741292 | — | Ki | = | 0.79 | nM | 9.10 |
| CHEMBL3740925 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL42 | CLOZAPINE | Ki | = | 12.9 | nM | 7.89 |
| CHEMBL3740256 | — | Ki | = | 15.7 | nM | 7.80 |
| CHEMBL3740807 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL3742070 | — | Ki | = | 26.9 | nM | 7.57 |
| CHEMBL3739523 | — | Ki | = | 26.9 | nM | 7.57 |
| CHEMBL3740680 | — | Ki | = | 30.1 | nM | 7.52 |
| CHEMBL3740811 | — | Ki | = | 32.6 | nM | 7.49 |
| CHEMBL3741698 | — | Ki | = | 66.8 | nM | 7.17 |
| CHEMBL3741140 | — | Ki | = | 71.8 | nM | 7.14 |
| CHEMBL3742368 | — | Ki | = | 112.9 | nM | 6.95 |
| CHEMBL3741596 | — | Ki | = | 113.8 | nM | 6.94 |
| CHEMBL3740636 | — | Ki | = | 120.8 | nM | 6.92 |
| CHEMBL3740759 | — | Ki | = | 135.2 | nM | 6.87 |
| CHEMBL3742362 | — | Ki | = | 215.6 | nM | 6.67 |
| CHEMBL3741924 | — | Ki | = | 265.3 | nM | 6.58 |
| CHEMBL3741933 | — | Ki | = | 310.2 | nM | 6.51 |
| CHEMBL3742391 | — | Ki | = | 367.6 | nM | 6.43 |
| CHEMBL3742136 | — | Ki | = | 454.9 | nM | 6.34 |
| CHEMBL3741925 | — | Ki | = | 568.6 | nM | 6.25 |
| CHEMBL3739805 | — | Ki | = | 1098.2 | nM | 5.96 |
| CHEMBL3739935 | — | Ki | = | 1523.5 | nM | 5.82 |
| CHEMBL3741516 | — | Ki | = | 2115.0 | nM | 5.67 |
| CHEMBL3741553 | — | Ki | > | 10000.0 | nM | - |