Assay Detail
Binding
CHEMBL3744704
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human PTP-sigma (residues 1367 to 1948) using para-nitrophenylphosphate as substrate for 60 mins by fluorescence analysis
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein phosphatase S (CHEMBL2396508) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of novel protein tyrosine phosphatase sigma inhibitors promoting neurite extension.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.49 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1438439 | IRIGENOL | — | 1 | 6.30 |
| CHEMBL55415 | SCUTELLAREIN | — | 1 | 6.22 |
| CHEMBL3739950 | — | — | 1 | 6.10 |
| CHEMBL3740878 | — | — | 1 | 6.05 |
| CHEMBL398328 | — | — | 1 | 5.52 |
| CHEMBL28626 | MORIN | — | 1 | 5.37 |
| CHEMBL3740356 | — | — | 1 | 5.27 |
| CHEMBL3739990 | — | — | 1 | 5.18 |
| CHEMBL179166 | SODIUM ORTHOVANAD | — | 1 | 5.08 |
| CHEMBL8260 | BAICALEIN | 2.0 | 1 | 4.99 |
| CHEMBL3741920 | — | — | 1 | 4.98 |
| CHEMBL247484 | TRICETIN | — | 1 | 4.76 |
| CHEMBL3742081 | — | — | 1 | - |
| CHEMBL3739546 | — | — | 1 | - |
| CHEMBL309263 | — | — | 1 | - |
| CHEMBL3741913 | — | — | 1 | - |
| CHEMBL3288727 | — | — | 1 | - |
| CHEMBL3742073 | — | — | 1 | - |
| CHEMBL3741139 | — | — | 1 | - |
| CHEMBL3742307 | — | — | 1 | - |
| CHEMBL241609 | OROBOL | — | 1 | - |
| CHEMBL3741744 | — | — | 1 | - |
| CHEMBL1950539 | — | — | 1 | - |
| CHEMBL3740337 | — | — | 1 | - |
| CHEMBL3741864 | — | — | 1 | - |
| CHEMBL3740766 | — | — | 1 | - |
| CHEMBL3739836 | — | — | 1 | - |
| CHEMBL3741052 | — | — | 1 | - |
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | - |
| CHEMBL3740881 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1438439 | IRIGENOL | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL55415 | SCUTELLAREIN | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3739950 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3740878 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL398328 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL28626 | MORIN | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL3740356 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL3739990 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL179166 | SODIUM ORTHOVANAD | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL8260 | BAICALEIN | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL3741920 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL247484 | TRICETIN | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL3742081 | — | IC50 | - | — | - | |
| CHEMBL3739546 | — | IC50 | - | — | - | |
| CHEMBL309263 | — | IC50 | - | — | - | |
| CHEMBL3741913 | — | IC50 | - | — | - | |
| CHEMBL3288727 | — | IC50 | - | — | - | |
| CHEMBL3742073 | — | IC50 | - | — | - | |
| CHEMBL3741139 | — | IC50 | - | — | - | |
| CHEMBL3742307 | — | IC50 | - | — | - | |
| CHEMBL241609 | OROBOL | IC50 | - | — | - | |
| CHEMBL3741744 | — | IC50 | - | — | - | |
| CHEMBL1950539 | — | IC50 | - | — | - | |
| CHEMBL3740337 | — | IC50 | - | — | - | |
| CHEMBL3741864 | — | IC50 | - | — | - | |
| CHEMBL3740766 | — | IC50 | - | — | - | |
| CHEMBL3739836 | — | IC50 | - | — | - | |
| CHEMBL3741052 | — | IC50 | - | — | - | |
| CHEMBL150 | KAEMPFEROL | IC50 | - | — | - | |
| CHEMBL3740881 | — | IC50 | - | — | - |