Assay Detail
Functional
CHEMBL3745283
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 X4 expressing reverse transcriptase K103N mutant infected in human CD4+ T cells for 3 days by FACS analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | T-cell |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Potent Inhibitors Active against HIV Reverse Transcriptase with K101P, a Mutation Conferring Rilpivirine Resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.37 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3342974 | — | — | 1 | 8.52 |
| CHEMBL175691 | RILPIVIRINE | 4.0 | 1 | 7.89 |
| CHEMBL3342966 | — | — | 1 | 7.30 |
| CHEMBL1923492 | — | — | 1 | 7.05 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3342974 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL175691 | RILPIVIRINE | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3342966 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1923492 | — | EC50 | = | 89.0 | nM | 7.05 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 836.0 | nM | 6.08 |