Assay Detail
Functional
CHEMBL3749643
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antioxidant activity in albino rat brain homogenate assessed as inhibition of Fe(III)-induced lipid peroxidation after 60 mins by TBARS assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel 5-hydroxylaminoisoxazole derivatives as lipoxygenase inhibitors and metabolism enhancing agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.38 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3747483 | — | — | 1 | 5.92 |
| CHEMBL3745877 | — | — | 1 | 5.86 |
| CHEMBL3746105 | — | — | 1 | 5.83 |
| CHEMBL3747650 | — | — | 1 | 5.80 |
| CHEMBL3746867 | — | — | 1 | 5.28 |
| CHEMBL3746445 | — | — | 1 | 5.26 |
| CHEMBL3746662 | — | — | 1 | 4.66 |
| CHEMBL3746578 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3747483 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL3745877 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL3746105 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL3747650 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL3746867 | — | IC50 | = | 5250.0 | nM | 5.28 |
| CHEMBL3746445 | — | IC50 | = | 5450.0 | nM | 5.26 |
| CHEMBL3746662 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL3746578 | — | IC50 | = | 35000.0 | nM | 4.46 |