Assay Detail
Binding
CHEMBL3755092
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Binding affinity to recombinant human H3 receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Benzamide derivatives and their constrained analogs as histamine H3 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.99 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3753475 | — | — | 1 | 10.52 |
| CHEMBL3753901 | — | — | 1 | 10.00 |
| CHEMBL3753093 | — | — | 1 | 9.05 |
| CHEMBL3752655 | — | — | 1 | 9.00 |
| CHEMBL3753703 | — | — | 1 | 8.92 |
| CHEMBL2103862 | BAVISANT | 2.0 | 1 | 8.27 |
| CHEMBL476323 | MK-0249 | 2.0 | 1 | 8.17 |
| CHEMBL3092650 | GSK239512 | 2.0 | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3753475 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL3753901 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL3753093 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL3752655 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL3753703 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL2103862 | BAVISANT | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL476323 | MK-0249 | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL3092650 | GSK239512 | Ki | = | 10.0 | nM | 8.00 |