Compound Detail
CHEMBL2103862
BAVISANT 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL2103862 |
| Name | BAVISANT |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | BGBVSGSIXIIREO-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
2
Known Names
2
Indications
1
Mechanisms
Molecular Properties
329.4
MW (Da)
1.44
ALogP
4
HBA
0
HBD
36.0
PSA (Ų)
0.84
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Histamine H3 receptor antagonist | ANTAGONIST | Histamine H3 receptor | ✓ | ✓ |
Indications
Alcoholism Attention Deficit Disorder with Hyperactivity
Activity Summary
Ki 2 meas. best 8.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H3 receptor CHEMBL264 | Ki | 8.3 | 8.285 | 5.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histamine H3 receptor | Ki | = | 5.012 | nM | 8.3 | Antagonist activity at human Histamine H3 receptor | 38393759 |
| Histamine H3 receptor | Ki | = | 5.4 | nM | 8.27 | Binding affinity to recombinant human H3 receptor | 26731168 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 26731168 | 10.1016/j.ejmech.2015.12.005 | Histamine H3 receptor | 1 |
| 38393759 | 10.1021/acs.jmedchem.3c02117 | Histamine H3 receptor | 1 |
Data from ChEMBL 36 via Core Engine