Assay Detail
Binding
CHEMBL3756313
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]citalopram from SERT in Sprague-Dawley rat whole brain membranes after 1 hr by liquid scintillation spectrometry
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
The influence of 5-HT(2A) activity on a 5-HT(2C) specific in vivo assay used for early identification of multiple acting SERT and 5-HT(2C) receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.16 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3261686 | — | — | 1 | 8.05 |
| CHEMBL3753894 | — | — | 1 | 7.69 |
| CHEMBL3752844 | — | — | 1 | 7.58 |
| CHEMBL3753681 | — | — | 1 | 7.53 |
| CHEMBL3752059 | — | — | 1 | 7.43 |
| CHEMBL3261690 | — | — | 1 | 7.42 |
| CHEMBL3261695 | — | — | 1 | 7.39 |
| CHEMBL3261693 | — | — | 1 | 7.21 |
| CHEMBL3753516 | — | — | 1 | 7.18 |
| CHEMBL3752465 | — | — | 1 | 7.18 |
| CHEMBL3754137 | — | — | 1 | 7.03 |
| CHEMBL3753283 | — | — | 1 | 6.96 |
| CHEMBL3753329 | — | — | 1 | 6.68 |
| CHEMBL3754784 | — | — | 1 | 6.29 |
| CHEMBL14563 | SB-242084 | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3261686 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL3753894 | — | Ki | = | 20.4 | nM | 7.69 |
| CHEMBL3752844 | — | Ki | = | 26.2 | nM | 7.58 |
| CHEMBL3753681 | — | Ki | = | 29.7 | nM | 7.53 |
| CHEMBL3752059 | — | Ki | = | 36.8 | nM | 7.43 |
| CHEMBL3261690 | — | Ki | = | 37.9 | nM | 7.42 |
| CHEMBL3261695 | — | Ki | = | 41.1 | nM | 7.39 |
| CHEMBL3261693 | — | Ki | = | 61.4 | nM | 7.21 |
| CHEMBL3753516 | — | Ki | = | 65.6 | nM | 7.18 |
| CHEMBL3752465 | — | Ki | = | 65.5 | nM | 7.18 |
| CHEMBL3754137 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL3753283 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL3753329 | — | Ki | = | 209.0 | nM | 6.68 |
| CHEMBL3754784 | — | Ki | = | 509.0 | nM | 6.29 |
| CHEMBL14563 | SB-242084 | Ki | = | 1772.0 | nM | 5.75 |