Assay Detail
Binding
CHEMBL3756315
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]ketanserin from 5HT2A in Wistar rat frontal cortex membranes after 1 hr by liquid scintillation spectrometry
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Frontal cortex |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The influence of 5-HT(2A) activity on a 5-HT(2C) specific in vivo assay used for early identification of multiple acting SERT and 5-HT(2C) receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.20 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3753894 | — | — | 1 | 8.52 |
| CHEMBL3753681 | — | — | 1 | 8.00 |
| CHEMBL3752844 | — | — | 1 | 7.23 |
| CHEMBL3752465 | — | — | 1 | 6.86 |
| CHEMBL3261695 | — | — | 1 | 6.63 |
| CHEMBL3261686 | — | — | 1 | 6.62 |
| CHEMBL14563 | SB-242084 | — | 1 | 6.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3753894 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL3753681 | — | Ki | = | 9.9 | nM | 8.00 |
| CHEMBL3752844 | — | Ki | = | 58.4 | nM | 7.23 |
| CHEMBL3752465 | — | Ki | = | 138.0 | nM | 6.86 |
| CHEMBL3261695 | — | Ki | = | 233.0 | nM | 6.63 |
| CHEMBL3261686 | — | Ki | = | 239.0 | nM | 6.62 |
| CHEMBL14563 | SB-242084 | Ki | = | 274.0 | nM | 6.56 |