Assay Detail
Functional
CHEMBL3756537
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Anti-inflammatory activity in human THP1 cells assessed as inhibition of PMA-induced IL-1beta production after 48 hrs by ELISA
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Three-component, one-pot synthesis of benzo[6,7]cyclohepta[1,2-b]pyridine derivatives under catalyst free conditions and evaluation of their anti-inflammatory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.96 | 5.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3751875 | — | — | 1 | 5.19 |
| CHEMBL572698 | — | — | 1 | 5.16 |
| CHEMBL3754375 | — | — | 1 | 5.09 |
| CHEMBL3752262 | — | — | 1 | 5.07 |
| CHEMBL3752364 | — | — | 1 | 4.76 |
| CHEMBL527 | PIROXICAM | 4.0 | 1 | 4.74 |
| CHEMBL3754105 | — | — | 1 | 4.74 |
| CHEMBL3754044 | — | — | 1 | - |
| CHEMBL3752608 | — | — | 1 | - |
| CHEMBL3754356 | — | — | 1 | - |
| CHEMBL3751919 | — | — | 1 | - |
| CHEMBL3754400 | — | — | 1 | - |
| CHEMBL3752197 | — | — | 1 | - |
| CHEMBL583491 | — | — | 1 | - |
| CHEMBL3753728 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3751875 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL572698 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL3754375 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL3752262 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL3752364 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL527 | PIROXICAM | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL3754105 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL3754044 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3752608 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3754356 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3751919 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3754400 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3752197 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL583491 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3753728 | — | IC50 | > | 20000.0 | nM | - |