Assay Detail
Functional
CHEMBL3756914
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Vasodilator activity in Sprague-Dawley rat mesentric artery assessed as reduction in of K+-induced contraction
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Mesenteric artery |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and fluorescent study of 5-phenyl furocoumarin derivatives as vasodilatory agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 5.52 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 7.51 |
| CHEMBL3753008 | — | — | 1 | 5.81 |
| CHEMBL3752581 | — | — | 1 | 5.59 |
| CHEMBL3754147 | — | — | 1 | 5.38 |
| CHEMBL3752205 | — | — | 1 | 5.35 |
| CHEMBL3751942 | — | — | 1 | 5.27 |
| CHEMBL3754459 | — | — | 1 | 5.15 |
| CHEMBL453805 | PENTOSALEN | -1.0 | 1 | 4.95 |
| CHEMBL3753669 | — | — | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6966 | VERAPAMIL | EC50 | = | 30.9 | nM | 7.51 |
| CHEMBL3753008 | — | EC50 | = | 1548.82 | nM | 5.81 |
| CHEMBL3752581 | — | EC50 | = | 2570.4 | nM | 5.59 |
| CHEMBL3754147 | — | EC50 | = | 4168.69 | nM | 5.38 |
| CHEMBL3752205 | — | EC50 | = | 4466.84 | nM | 5.35 |
| CHEMBL3751942 | — | EC50 | = | 5370.32 | nM | 5.27 |
| CHEMBL3754459 | — | EC50 | = | 7079.46 | nM | 5.15 |
| CHEMBL453805 | PENTOSALEN | EC50 | = | 11220.18 | nM | 4.95 |
| CHEMBL3753669 | — | EC50 | = | 19498.45 | nM | 4.71 |