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Compound Detail

CHEMBL3752205

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COC(=O)c1ccccc1-c1c2ccoc2c(OCCN2CCCCC2)c2oc(=O)ccc12

Basic Information

ChEMBL ID CHEMBL3752205
Phase Preclinical
Structure Type MOL
InChI Key BEUDUUUANLHQIE-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

447.5
MW (Da)
4.86
ALogP
7
HBA
0
HBD
82.1
PSA (Ų)
0.31
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H25NO6
MW 447.49
Aromatic Rings 4
Heavy Atoms 33
NP-Likeness 0.12

Activity Summary

EC50 1 meas. best 5.35

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Molecular identity unknown
CHEMBL612546
EC50 5.35 5.35 4466.8 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
26627580 10.1016/j.bmcl.2015.11.056 Molecular identity unknown 2

Data from ChEMBL 36 via Core Engine