Assay Detail
Binding
CHEMBL3757320
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human EP1 receptor
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Prostaglandin E2 receptor EP1 subtype (CHEMBL1811) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of highly potent dual EP(2) and EP(3) agonists with subtype selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.32 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3753268 | — | — | 1 | 7.05 |
| CHEMBL3753853 | — | — | 1 | 6.92 |
| CHEMBL3752435 | — | — | 1 | 6.83 |
| CHEMBL3753221 | — | — | 1 | 6.66 |
| CHEMBL3752406 | — | — | 1 | 6.37 |
| CHEMBL3753622 | — | — | 1 | 6.10 |
| CHEMBL3751951 | — | — | 1 | 5.97 |
| CHEMBL3754197 | — | — | 1 | 5.88 |
| CHEMBL3753898 | — | — | 1 | 5.08 |
| CHEMBL3753788 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3753268 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL3753853 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL3752435 | — | Ki | = | 149.0 | nM | 6.83 |
| CHEMBL3753221 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL3752406 | — | Ki | = | 431.0 | nM | 6.37 |
| CHEMBL3753622 | — | Ki | = | 802.0 | nM | 6.10 |
| CHEMBL3751951 | — | Ki | = | 1080.0 | nM | 5.97 |
| CHEMBL3754197 | — | Ki | = | 1332.0 | nM | 5.88 |
| CHEMBL3753898 | — | Ki | = | 8418.0 | nM | 5.08 |
| CHEMBL3753788 | — | Ki | > | 10000.0 | nM | - |