Compound Detail
CHEMBL3753268
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Basic Information
| ChEMBL ID | CHEMBL3753268 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NTMLORZSAFILHZ-HMRWBYCRSA-N |
4
Targets
4
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
436.6
MW (Da)
3.26
ALogP
7
HBA
2
HBD
100.0
PSA (Ų)
0.35
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 7.75
Ki 1 meas. best 7.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Prostaglandin E2 receptor EP3 subtype CHEMBL3710 | EC50 | 7.75 | 7.75 | 18.0 | 1 |
| Prostaglandin E2 receptor EP2 subtype CHEMBL1881 | EC50 | 7.68 | 7.68 | 21.0 | 1 |
| Prostaglandin E2 receptor EP1 subtype CHEMBL1811 | Ki | 7.05 | 7.05 | 89.0 | 1 |
| Prostaglandin E2 receptor EP4 subtype CHEMBL1836 | EC50 | 6.62 | 6.62 | 240.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Prostaglandin E2 receptor EP3 subtype | EC50 | = | 18.0 | nM | 7.75 | Agonist activity at human EP3 receptor | 26725951 |
| Prostaglandin E2 receptor EP2 subtype | EC50 | = | 21.0 | nM | 7.68 | Agonist activity at human EP2 receptor | 26725951 |
| Prostaglandin E2 receptor EP1 subtype | Ki | = | 89.0 | nM | 7.05 | Binding affinity to human EP1 receptor | 26725951 |
| Prostaglandin E2 receptor EP4 subtype | EC50 | = | 240.0 | nM | 6.62 | Agonist activity at human EP4 receptor | 26725951 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26725951 | 10.1016/j.bmcl.2015.12.039 | Prostaglandin E2 receptor EP2 subtype | 1 |
| 26725951 | 10.1016/j.bmcl.2015.12.039 | Prostaglandin E2 receptor EP3 subtype | 1 |
| 26725951 | 10.1016/j.bmcl.2015.12.039 | Prostaglandin E2 receptor EP4 subtype | 1 |
| 26725951 | 10.1016/j.bmcl.2015.12.039 | Prostaglandin E2 receptor EP1 subtype | 1 |
Data from ChEMBL 36 via Core Engine