Assay Detail
Binding
CHEMBL3757724
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to sigma-1 receptor (unknown origin) by radioligand displacement assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL287) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Role of the phenolic OH moiety of GluN2B-selective NMDA antagonists with 3-benzazepine scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.89 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.20 |
| CHEMBL3752701 | — | — | 1 | 7.51 |
| CHEMBL282433 | DITOLYLGUANIDINE | — | 1 | 7.05 |
| CHEMBL319706 | (S)-IFENPRODIL | — | 1 | 6.90 |
| CHEMBL1289626 | — | — | 1 | 6.71 |
| CHEMBL3753409 | — | — | 1 | 6.17 |
| CHEMBL3752293 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL3752701 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL282433 | DITOLYLGUANIDINE | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL319706 | (S)-IFENPRODIL | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL1289626 | — | Ki | = | 194.0 | nM | 6.71 |
| CHEMBL3753409 | — | Ki | = | 676.0 | nM | 6.17 |
| CHEMBL3752293 | — | Ki | = | 2200.0 | nM | 5.66 |