Assay Detail
Functional
CHEMBL3761141
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Antiproliferative activity against human HCT116 cells after 24 to 72 hrs by SRB assay
10
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antitumor Activity of Americanin A Isolated from the Seeds of Phytolacca americana by Regulating the ATM/ATR Signaling Pathway and the Skp2-p27 Axis in Human Colon Cancer Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.27 | 5.70 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL481 | IRINOTECAN | 4.0 | 1 | 5.70 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.48 |
| CHEMBL3759918 | — | — | 1 | 5.40 |
| CHEMBL3759078 | — | — | 1 | 5.25 |
| CHEMBL482240 | AMERICANIN A | — | 2 | 5.12 |
| CHEMBL3759382 | — | — | 1 | 4.98 |
| CHEMBL3758343 | — | — | 1 | 4.96 |
| CHEMBL3758680 | — | — | 1 | - |
| CHEMBL2442726 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL481 | IRINOTECAN | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL3759918 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3759078 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL482240 | AMERICANIN A | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL3759382 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL3758343 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL482240 | AMERICANIN A | Activity | - | — | - | |
| CHEMBL3758680 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2442726 | — | IC50 | > | 100000.0 | nM | - |