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Assay Detail

CHEMBL3761380

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human Jurkat cells assessed as cell growth inhibition after 48 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type Jurkat
Confidence 1 — Organism
Curated By Autocuration

Target

Jurkat (CHEMBL397)
Type CELL-LINE
Organism Homo sapiens

Publication

Anti-herpetic and anti-dengue activity of abietane ferruginol analogues synthesized from (+)-dehydroabietylamine.
Roa-Linares VC, Brand YM, Agudelo-Gomez LS, Tangarife-Castaño V, Betancur-Galvis LA, Gallego-Gomez JC, González MA.
Eur J Med Chem (2016) 108 : 79 -88
PubMed 26638041 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.58 9.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL428647 PACLITAXEL 4.0 1 9.30
CHEMBL53463 DOXORUBICIN 4.0 1 7.92
CHEMBL3338088 1 4.91
CHEMBL1277662 18-OXOFERRUGINOL 1 4.67
CHEMBL3338086 1 4.66
CHEMBL3758928 1 4.51
CHEMBL197308 FERRUGINOL 1 4.32
CHEMBL3338085 1 4.31
CHEMBL3338083 1 -
CHEMBL3338084 1 -
CHEMBL3338087 1 -
CHEMBL3758615 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL428647 PACLITAXEL IC50 = 0.5 nM 9.30
CHEMBL53463 DOXORUBICIN IC50 = 12.0 nM 7.92
CHEMBL3338088 IC50 = 12300.0 nM 4.91
CHEMBL1277662 18-OXOFERRUGINOL IC50 = 21600.0 nM 4.67
CHEMBL3338086 IC50 = 21900.0 nM 4.66
CHEMBL3758928 IC50 = 30900.0 nM 4.51
CHEMBL197308 FERRUGINOL IC50 = 48200.0 nM 4.32
CHEMBL3338085 IC50 = 49400.0 nM 4.31
CHEMBL3338083 IC50 > 50000.0 nM -
CHEMBL3338084 IC50 > 50000.0 nM -
CHEMBL3338087 IC50 > 40000.0 nM -
CHEMBL3758615 IC50 > 30000.0 nM -