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Assay Detail

CHEMBL3762577

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity at mu opioid receptor (unknown origin)
16
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Mu-type opioid receptor (CHEMBL233)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Multitarget opioid ligands in pain relief: New players in an old game.
Turnaturi R, Aricò G, Ronsisvalle G, Parenti C, Pasquinucci L.
Eur J Med Chem (2016) 108 : 211 -228
PubMed 26656913 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 15 9.29 11.00
IC50 1 7.43 7.43

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL326684 1 11.00
CHEMBL583066 1 10.80
CHEMBL3759292 1 10.51
CHEMBL3758712 1 10.38
CHEMBL301160 BUTORPHAN 1 9.92
CHEMBL2181202 1 9.85
CHEMBL3759238 1 9.42
CHEMBL3758259 1 9.33
CHEMBL3758292 1 9.30
CHEMBL3759092 1 9.08
CHEMBL3759383 1 9.03
CHEMBL538700 1 8.92
CHEMBL3759489 1 7.99
CHEMBL3758231 1 7.85
CHEMBL285479 1 7.43
CHEMBL3758257 1 5.98

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL326684 Ki = 0.01 nM 11.00
CHEMBL583066 Ki = 0.016 nM 10.80
CHEMBL3759292 Ki = 0.031 nM 10.51
CHEMBL3758712 Ki = 0.042 nM 10.38
CHEMBL301160 BUTORPHAN Ki = 0.12 nM 9.92
CHEMBL2181202 Ki = 0.143 nM 9.85
CHEMBL3759238 Ki = 0.38 nM 9.42
CHEMBL3758259 Ki = 0.47 nM 9.33
CHEMBL3758292 Ki = 0.5 nM 9.30
CHEMBL3759092 Ki = 0.83 nM 9.08
CHEMBL3759383 Ki = 0.94 nM 9.03
CHEMBL538700 Ki = 1.19 nM 8.92
CHEMBL3759489 Ki = 10.2 nM 7.99
CHEMBL3758231 Ki = 14.0 nM 7.85
CHEMBL285479 IC50 = 36.7 nM 7.43
CHEMBL3758257 Ki = 1050.0 nM 5.98