Assay Detail
Functional
CHEMBL3762660
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Agonist activity at human recombinant MOR expressed in CHO cells assessed as calcium mobilization by Fluo-4 AM based fluorescence analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of mixed MOR/KOR efficacy cyclic opioid peptide analogs with antinociceptive activity after systemic administration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.94 | 8.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1927270 | — | — | 1 | 8.69 |
| CHEMBL3759179 | — | — | 1 | 8.44 |
| CHEMBL3759167 | — | — | 1 | 8.25 |
| CHEMBL3759981 | — | — | 1 | 7.94 |
| CHEMBL333357 | ENDOMORPHIN 2 | — | 1 | 7.88 |
| CHEMBL3758969 | — | — | 1 | 7.70 |
| CHEMBL405618 | ANALOG OF DYNORPHIN A | — | 1 | 6.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1927270 | — | EC50 | = | 2.042 | nM | 8.69 |
| CHEMBL3759179 | — | EC50 | = | 3.631 | nM | 8.44 |
| CHEMBL3759167 | — | EC50 | = | 5.623 | nM | 8.25 |
| CHEMBL3759981 | — | EC50 | = | 11.48 | nM | 7.94 |
| CHEMBL333357 | ENDOMORPHIN 2 | EC50 | = | 13.18 | nM | 7.88 |
| CHEMBL3758969 | — | EC50 | = | 19.95 | nM | 7.70 |
| CHEMBL405618 | ANALOG OF DYNORPHIN A | EC50 | = | 213.8 | nM | 6.67 |