Assay Detail
Binding
CHEMBL3767073
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Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydration assay
35
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 35 | 5.63 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL183419 | CYANIDE | — | 1 | 6.30 |
| CHEMBL1200739 | HYDROGEN SULFIDE | — | 1 | 6.22 |
| CHEMBL1161700 | CYANATE | — | 1 | 6.16 |
| CHEMBL79455 | — | — | 1 | 5.92 |
| CHEMBL2079226 | ISOSELENOCYANATE | — | 1 | 5.07 |
| CHEMBL1207991 | CARBONOTRITHIOIC ACID | — | 1 | 5.06 |
| CHEMBL68253 | SULFAMATE | — | 1 | 4.68 |
| CHEMBL1362 | FLUORIDE ION | 3.0 | 1 | - |
| CHEMBL1161632 | BICARBONATE | 3.0 | 2 | - |
| CHEMBL1161634 | PERCHLORATE | — | 1 | - |
| CHEMBL1789400 | — | — | 1 | - |
| CHEMBL2097002 | SELENIC ACID | 3.0 | 1 | - |
| CHEMBL1207990 | — | — | 1 | - |
| CHEMBL355001 | SULFAMIDE | — | 1 | - |
| CHEMBL21485 | PHENYLBORONIC ACID | — | 1 | - |
| CHEMBL364571 | PHENYLARSONIC ACID | — | 1 | - |
| CHEMBL1233550 | IODIDE | -1.0 | 1 | - |
| CHEMBL1161685 | ISOTHIOCYANATE | — | 1 | - |
| CHEMBL1231821 | HYDROCHLORIC ACID | -1.0 | 1 | - |
| CHEMBL1231461 | BROMIDE | — | 1 | - |
| CHEMBL1160571 | PYROPHOSPHORIC ACID | 2.0 | 1 | - |
| CHEMBL2097021 | — | — | 1 | - |
| CHEMBL2096999 | — | — | 1 | - |
| CHEMBL2097011 | BORAX | — | 1 | - |
| CHEMBL2097029 | — | — | 1 | - |
| CHEMBL2097025 | — | — | 1 | - |
| CHEMBL1208163 | — | — | 1 | - |
| CHEMBL961 | DITIOCARB | 2.0 | 1 | - |
| CHEMBL1207889 | — | — | 1 | - |
| CHEMBL572964 | SULFURIC ACID | -1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL183419 | CYANIDE | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL1200739 | HYDROGEN SULFIDE | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL1161700 | CYANATE | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL79455 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL2079226 | ISOSELENOCYANATE | Ki | = | 8500.0 | nM | 5.07 |
| CHEMBL1207991 | CARBONOTRITHIOIC ACID | Ki | = | 8700.0 | nM | 5.06 |
| CHEMBL68253 | SULFAMATE | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL1789400 | — | Ki | > | 200000000.0 | nM | - |
| CHEMBL2097020 | — | Ki | = | 570000.0 | nM | - |
| CHEMBL1207889 | — | Ki | = | 790000.0 | nM | - |
| CHEMBL2097002 | SELENIC ACID | Ki | = | 118000000.0 | nM | - |
| CHEMBL355001 | SULFAMIDE | Ki | = | 310000.0 | nM | - |
| CHEMBL21485 | PHENYLBORONIC ACID | Ki | = | 58600000.0 | nM | - |
| CHEMBL364571 | PHENYLARSONIC ACID | Ki | = | 31700000.0 | nM | - |
| CHEMBL1233550 | IODIDE | Ki | = | 300000.0 | nM | - |
| CHEMBL1161685 | ISOTHIOCYANATE | Ki | = | 200000.0 | nM | - |
| CHEMBL1161632 | BICARBONATE | Ki | = | 12000000.0 | nM | - |
| CHEMBL1161632 | BICARBONATE | Ki | = | 15000000.0 | nM | - |
| CHEMBL186200 | — | Ki | = | 7000000.0 | nM | - |
| CHEMBL1161681 | NITROUS ACID | Ki | = | 8400000.0 | nM | - |
| CHEMBL1161699 | SULFUROUS ACID | Ki | = | 18000000.0 | nM | - |
| CHEMBL1161634 | PERCHLORATE | Ki | > | 200000000.0 | nM | - |
| CHEMBL1362 | FLUORIDE ION | Ki | > | 300000000.0 | nM | - |
| CHEMBL1231821 | HYDROCHLORIC ACID | Ki | = | 6000000.0 | nM | - |
| CHEMBL1231461 | BROMIDE | Ki | = | 4000000.0 | nM | - |
| CHEMBL1160571 | PYROPHOSPHORIC ACID | Ki | = | 25800000.0 | nM | - |
| CHEMBL2097021 | — | Ki | = | 660000.0 | nM | - |
| CHEMBL2096999 | — | Ki | = | 540000.0 | nM | - |
| CHEMBL1207990 | — | Ki | = | 310000.0 | nM | - |
| CHEMBL2097029 | — | Ki | = | 110000.0 | nM | - |
| CHEMBL2097025 | — | Ki | = | 101000.0 | nM | - |
| CHEMBL1208163 | — | Ki | = | 107000.0 | nM | - |
| CHEMBL961 | DITIOCARB | Ki | = | 790000.0 | nM | - |
| CHEMBL572964 | SULFURIC ACID | Ki | = | 63000000.0 | nM | - |
| CHEMBL2097011 | BORAX | Ki | = | 640000.0 | nM | - |