Assay Detail
Functional
CHEMBL3767226
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antihyperproliferative activity against human HaCaT cells after 48 hrs by phase contrast microscopic analysis
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HaCaT |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
8-Halo-substituted naphtho[2,3-b]thiophene-4,9-diones as redox-active inhibitors of keratinocyte hyperproliferation with reduced membrane-damaging properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.59 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3314725 | — | — | 1 | 6.40 |
| CHEMBL93347 | — | — | 1 | 6.36 |
| CHEMBL3763859 | — | — | 1 | 6.24 |
| CHEMBL3765668 | — | — | 1 | 6.23 |
| CHEMBL46469 | ANTHRALIN | 2.0 | 1 | 6.16 |
| CHEMBL3765251 | — | — | 1 | 6.14 |
| CHEMBL3763894 | — | — | 1 | 6.05 |
| CHEMBL3765520 | — | — | 1 | 5.98 |
| CHEMBL3763885 | — | — | 1 | 5.91 |
| CHEMBL3314727 | — | — | 1 | 5.89 |
| CHEMBL3763656 | — | — | 1 | 5.82 |
| CHEMBL3763287 | — | — | 1 | 5.81 |
| CHEMBL3765210 | — | — | 1 | 5.76 |
| CHEMBL3764146 | — | — | 1 | 5.75 |
| CHEMBL3764693 | — | — | 1 | 5.66 |
| CHEMBL3763346 | — | — | 1 | 5.56 |
| CHEMBL3764274 | — | — | 1 | 5.54 |
| CHEMBL3763723 | — | — | 1 | 5.42 |
| CHEMBL3314716 | — | — | 1 | 5.42 |
| CHEMBL3763748 | — | — | 1 | 5.33 |
| CHEMBL302418 | THIOPHENONAPHTHOQUINONE | — | 1 | 5.32 |
| CHEMBL3763784 | — | — | 1 | 5.31 |
| CHEMBL3763326 | — | — | 1 | 5.18 |
| CHEMBL3764584 | — | — | 1 | 5.07 |
| CHEMBL3763257 | — | — | 1 | 5.06 |
| CHEMBL3763756 | — | — | 1 | 4.98 |
| CHEMBL3763541 | — | — | 1 | 4.92 |
| CHEMBL3764961 | — | — | 1 | 4.88 |
| CHEMBL3765647 | — | — | 1 | 4.83 |
| CHEMBL590 | MENADIONE | 4.0 | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3314725 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL93347 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL3763859 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL3765668 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL46469 | ANTHRALIN | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3765251 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL3763894 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3765520 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL3763885 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL3314727 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL3763656 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3763287 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL3765210 | — | IC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL3764146 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL3764693 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3763346 | — | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL3764274 | — | IC50 | = | 2910.0 | nM | 5.54 |
| CHEMBL3763723 | — | IC50 | = | 3820.0 | nM | 5.42 |
| CHEMBL3314716 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL3763748 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL302418 | THIOPHENONAPHTHOQUINONE | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL3763784 | — | IC50 | = | 4850.0 | nM | 5.31 |
| CHEMBL3763326 | — | IC50 | = | 6640.0 | nM | 5.18 |
| CHEMBL3764584 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL3763257 | — | IC50 | = | 8630.0 | nM | 5.06 |
| CHEMBL3763756 | — | IC50 | = | 10470.0 | nM | 4.98 |
| CHEMBL3763541 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL3764961 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL3765647 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL590 | MENADIONE | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL3764814 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3763313 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3765602 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3764715 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3765556 | — | IC50 | > | 30000.0 | nM | - |