Assay Detail
Binding
CHEMBL3767816
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 5-(Dimethylamino)-2-(6-((5-(4-(4-methylpiperidin-1-yl)butyl)-5,6,7,8-tetrahydronaphthalen-2-yl)oxy)hexyl)isoindoline-1,3-dione from sigma 1 receptor (unknown origin) expressed in MCF7 after 75 mins by flow cytometry
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL287) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of sigma-1 (σ1) receptor fluorescent ligands as versatile tools to study σ1 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.88 | 7.95 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL177952 | — | — | 2 | 7.95 |
| CHEMBL176941 | — | — | 2 | 7.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL177952 | — | IC50 | = | 11.3 | nM | 7.95 |
| CHEMBL176941 | — | IC50 | = | 15.5 | nM | 7.81 |
| CHEMBL177952 | — | Activity | - | — | - | |
| CHEMBL176941 | — | Activity | - | — | - |