Assay Detail
Functional
CHEMBL3768183
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Antiviral activity against clinical isolates of Dengue virus 1 Indonesia JKT 1186 TVP 949 infected in African green monkey Vero E6 cells assessed as reduction in viral RNA after 4 days by qRT-PCR method
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | dengue virus type 1 |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel 2-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,3,4-oxadiazole and 3-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,2,4-oxadiazole derivatives as dengue virus inhibitors targeting NS5 polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 5.30 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1630221 | — | — | 1 | 6.07 |
| CHEMBL3763966 | — | — | 1 | 5.70 |
| CHEMBL3764484 | — | — | 1 | 5.60 |
| CHEMBL3765487 | — | — | 1 | 5.23 |
| CHEMBL3764002 | — | — | 1 | 5.16 |
| CHEMBL3765560 | — | — | 1 | 5.12 |
| CHEMBL3764674 | — | — | 1 | 5.04 |
| CHEMBL3764653 | — | — | 1 | 4.96 |
| CHEMBL3765453 | — | — | 1 | 4.82 |
| CHEMBL3764522 | — | — | 1 | - |
| CHEMBL3765002 | — | — | 1 | - |
| CHEMBL3765469 | — | — | 1 | - |
| CHEMBL3765813 | — | — | 1 | - |
| CHEMBL3764461 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1630221 | — | EC50 | = | 860.0 | nM | 6.07 |
| CHEMBL3763966 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3764484 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3765487 | — | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL3764002 | — | EC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL3765560 | — | EC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL3764674 | — | EC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL3764653 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3765453 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3764522 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3765002 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3765469 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3765813 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3764461 | — | EC50 | > | 20000.0 | nM | - |