Assay Detail
Binding
CHEMBL3768199
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of 2-arylfuro[3,2-b]pyridines: Effect of the C2-aryl group on melatoninergic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 8.31 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3765540 | — | — | 1 | 10.40 |
| CHEMBL323332 | — | — | 1 | 9.82 |
| CHEMBL3765401 | — | — | 1 | 9.70 |
| CHEMBL3763503 | — | — | 1 | 9.70 |
| CHEMBL1760944 | — | — | 1 | 9.62 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.60 |
| CHEMBL3763281 | — | — | 1 | 8.80 |
| CHEMBL3764765 | — | — | 1 | 8.66 |
| CHEMBL3765249 | — | — | 1 | 8.02 |
| CHEMBL3764063 | — | — | 1 | 7.51 |
| CHEMBL137969 | — | — | 1 | 7.40 |
| CHEMBL3763537 | — | — | 1 | 7.17 |
| CHEMBL3763247 | — | — | 1 | 7.14 |
| CHEMBL3764421 | — | — | 1 | 6.92 |
| CHEMBL3764879 | — | — | 1 | 6.70 |
| CHEMBL2326199 | — | — | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3765540 | — | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL323332 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL3765401 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL3763503 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL1760944 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL45 | MELATONIN | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL3763281 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL3764765 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL3765249 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL3764063 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL137969 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL3763537 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL3763247 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL3764421 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL3764879 | — | Ki | = | 198.0 | nM | 6.70 |
| CHEMBL2326199 | — | Ki | = | 1350.0 | nM | 5.87 |