Assay Detail
Binding
CHEMBL3768359
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Inhibition of ATM kinase in human MCF7 cells after 1 hr by immunofluorescence assay
73
Total Activities
73
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of a Novel Series of Ataxia-Telangiectasia Mutated Kinase Inhibitors as Potential Radiosensitizing Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 73 | 5.46 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222102 | KU-55933 | — | 1 | 6.52 |
| CHEMBL2143829 | — | — | 1 | 6.40 |
| CHEMBL3764231 | — | — | 1 | 6.10 |
| CHEMBL3763939 | — | — | 1 | 6.10 |
| CHEMBL3765373 | — | — | 1 | 6.10 |
| CHEMBL3763565 | — | — | 1 | 6.05 |
| CHEMBL3764768 | — | — | 1 | 6.00 |
| CHEMBL3763358 | — | — | 1 | 5.92 |
| CHEMBL3764022 | — | — | 1 | 5.92 |
| CHEMBL3763863 | — | — | 1 | 5.80 |
| CHEMBL3764372 | — | — | 1 | 5.80 |
| CHEMBL3763259 | — | — | 1 | 5.77 |
| CHEMBL3764983 | — | — | 1 | 5.77 |
| CHEMBL3765095 | — | — | 1 | 5.72 |
| CHEMBL3763603 | — | — | 1 | 5.70 |
| CHEMBL3764633 | — | — | 1 | 5.68 |
| CHEMBL3764051 | — | — | 1 | 5.66 |
| CHEMBL3764300 | — | — | 1 | 5.64 |
| CHEMBL3764371 | — | — | 1 | 5.62 |
| CHEMBL3763333 | — | — | 1 | 5.57 |
| CHEMBL3764626 | — | — | 1 | 5.54 |
| CHEMBL3765732 | — | — | 1 | 5.30 |
| CHEMBL3763327 | — | — | 1 | 5.28 |
| CHEMBL3763767 | — | — | 1 | 5.28 |
| CHEMBL3764577 | — | — | 1 | 5.25 |
| CHEMBL3765728 | — | — | 1 | 5.21 |
| CHEMBL3765428 | — | — | 1 | 5.18 |
| CHEMBL3763312 | — | — | 1 | 5.07 |
| CHEMBL3765484 | — | — | 1 | 5.00 |
| CHEMBL3764259 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222102 | KU-55933 | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2143829 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3763939 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3765373 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3764231 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3763565 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3764768 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3763358 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3764022 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3763863 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3764372 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3763259 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3764983 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3765095 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3763603 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3764633 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3764051 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3764300 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3764371 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL3763333 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL3764626 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL3765732 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3763327 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL3763767 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL3764577 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL3765728 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL3765428 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL3763312 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL3765484 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL3764259 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL3764148 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL3763556 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL3763903 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3763403 | — | IC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL3765799 | — | IC50 | = | 20600.0 | nM | 4.69 |
| CHEMBL3765248 | — | IC50 | = | 23500.0 | nM | 4.63 |
| CHEMBL3763843 | — | IC50 | = | 28600.0 | nM | 4.54 |
| CHEMBL3764171 | — | IC50 | = | 31100.0 | nM | 4.51 |
| CHEMBL3763579 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL3763978 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL3764741 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL3764897 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL3765342 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL3765418 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL3765296 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL3763710 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL3764689 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL3764232 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL3763586 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL3764242 | — | IC50 | > | 40000.0 | nM | - |