Assay Detail
Binding
CHEMBL3768874
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Inhibition of DAGLbeta (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure activity relationship studies on chemically non-reactive glycine sulfonamide inhibitors of diacylglycerol lipase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.01 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3764876 | — | — | 1 | 7.40 |
| CHEMBL3764017 | — | — | 1 | 7.40 |
| CHEMBL3764093 | — | — | 1 | 7.10 |
| CHEMBL3765022 | — | — | 1 | 6.95 |
| CHEMBL3765421 | — | — | 1 | 6.84 |
| CHEMBL175247 | ORLISTAT | 4.0 | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3764876 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3764017 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3764093 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3765022 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL3765421 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL175247 | ORLISTAT | IC50 | = | 420.0 | nM | 6.38 |