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Target Snapshot

CHEMBL5521 Target Snapshot

Diacylglycerol lipase-beta · SINGLE PROTEIN · Homo sapiens

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70Compounds
10Assays
1Approved Drugs
68.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q8NCG7. Use UniProt Q8NCG7 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q8NCG7 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Diacylglycerol lipase-beta as ChEMBL target CHEMBL5521, mapped to UniProt Q8NCG7. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Diacylglycerol lipase-beta
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL5521
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q8NCG7
Diacylglycerol lipase-beta
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Diacylglycerol lipase-beta is the right protein anchor across sources, using UniProt Q8NCG7 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameDiacylglycerol lipase-beta
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ8NCG7
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelDiacylglycerol lipase-beta
UniProt AccessionQ8NCG7
Component TypeProtein
Sequence Length672 aa

Diacylglycerol lipase-beta

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Diacylglycerol lipase-beta, mapped to UniProt Q8NCG7. Sequence length is 672 aa.

Mapped IDQ8NCG7
Review nameDiacylglycerol lipase-beta
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC5068.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4470017 8.2 IC50 6.31 Preclinical
CHEMBL4476210 7.6 IC50 25.12 Preclinical
CHEMBL3764017 7.4 IC50 40.0 Preclinical
CHEMBL3764876 7.4 IC50 40.0 Preclinical
CHEMBL158897 7.22 IC50 60.0 Preclinical
CHEMBL175247 7.22 IC50 60.0 Approved
CHEMBL3764093 7.1 IC50 80.0 Preclinical
CHEMBL3765022 6.95 IC50 112.0 Preclinical
CHEMBL3765421 6.84 IC50 146.0 Preclinical
CHEMBL5742950 5.92 IC50 1200.0 Preclinical
Distribution

pChEMBL Value Distribution

18
5.0
9
5.5
1
6.0
2
6.5
5
7.0
1
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

ORLISTAT
CHEMBL175247
Approved 1998
Properties Compare Identifier
Assay Landscape

Assay Landscape

10
Total Assays
37
Tested Compounds
2
Assay Types
Binding — 9 assays, 37 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 7 4 7.6
assay format 1 27 5.5
single protein format 1 6 7.0
Functional — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine