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Compound Detail

CHEMBL3764876

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O=C(O)CN(c1cccc(-c2cccc(Cl)c2Cl)c1)S(=O)(=O)c1ccc(OC(F)F)cc1

Basic Information

ChEMBL ID CHEMBL3764876
Phase Preclinical
Structure Type MOL
InChI Key VHRMEONQZIUMOQ-UHFFFAOYSA-N
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

502.3
MW (Da)
5.54
ALogP
4
HBA
1
HBD
83.9
PSA (Ų)
0.44
QED
2
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H15Cl2F2NO5S
MW 502.32
Aromatic Rings 3
Heavy Atoms 32
NP-Likeness -1.62

Activity Summary

IC50 3 meas. best 8.62

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Diacylglycerol lipase-alpha
CHEMBL5545
IC50 8.62 8.23 2.4 2
Diacylglycerol lipase-beta
CHEMBL5521
IC50 7.4 7.4 40.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
26917221 10.1016/j.bmc.2016.02.006 Diacylglycerol lipase-alpha 2
26917221 10.1016/j.bmc.2016.02.006 Monoglyceride lipase 1
26917221 10.1016/j.bmc.2016.02.006 Mus musculus 1
26917221 10.1016/j.bmc.2016.02.006 Diacylglycerol lipase-beta 1

Data from ChEMBL 36 via Core Engine