Compound Detail
CHEMBL5742950
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Basic Information
| ChEMBL ID | CHEMBL5742950 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AXZSASWLSVUURE-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
430.4
MW (Da)
4.91
ALogP
5
HBA
0
HBD
60.2
PSA (Ų)
0.56
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Diacylglycerol lipase-beta CHEMBL5521 | IC50 | 5.92 | 5.92 | 1200.0 | 1 |
| Diacylglycerol lipase-alpha CHEMBL5545 | IC50 | 5.22 | 5.22 | 6000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Diacylglycerol lipase-beta | IC50 | = | 1200.0 | nM | 5.92 | In Vitro Inhibition of DAGL: Briefly, membrane proteome (1 mg/ml, 20 μL) was pre... | - |
| Diacylglycerol lipase-alpha | IC50 | = | 6000.0 | nM | 5.22 | In Vitro Inhibition of DAGL: Briefly, membrane proteome (1 mg/ml, 20 μL) was pre... | - |
Data from ChEMBL 36 via Core Engine