Assay Detail
ADMET
CHEMBL3768882
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Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate incubated for 7 mins by LC-MS analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure activity relationship studies on chemically non-reactive glycine sulfonamide inhibitors of diacylglycerol lipase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.77 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3765022 | — | — | 1 | 5.40 |
| CHEMBL3764017 | — | — | 1 | 4.89 |
| CHEMBL3764044 | — | — | 1 | 4.40 |
| CHEMBL3764377 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3765022 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3764017 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3764044 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL3764377 | — | IC50 | = | 40000.0 | nM | 4.40 |