Assay Detail
ADMET
CHEMBL3772007
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Inhibition of CYP3A4 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Orexin Receptor Antagonists: New Therapeutic Agents for the Treatment of Insomnia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.82 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3667554 | — | — | 1 | 5.10 |
| CHEMBL3597952 | ACT-462206 | 1.0 | 1 | 4.82 |
| CHEMBL3338866 | MK-1064 | 1.0 | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3667554 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL3597952 | ACT-462206 | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3338866 | MK-1064 | IC50 | = | 28000.0 | nM | 4.55 |