Assay Detail
Binding
CHEMBL3772096
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ROCK1 (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.49 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3770836 | — | — | 1 | 8.92 |
| CHEMBL3770730 | — | — | 1 | 8.22 |
| CHEMBL3426621 | RIPASUDIL | 3.0 | 1 | 7.29 |
| CHEMBL521179 | SR-3677 | — | 1 | 7.25 |
| CHEMBL559147 | Y-27632 | — | 1 | 6.70 |
| CHEMBL38380 | FASUDIL | 3.0 | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3770836 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3770730 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3426621 | RIPASUDIL | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL521179 | SR-3677 | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL559147 | Y-27632 | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL38380 | FASUDIL | IC50 | = | 260.0 | nM | 6.58 |