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Assay Detail

CHEMBL3772611

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human T47D cells assessed as reduction in cell viability after 96 hrs by sulforhodamine B assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type T47D
Confidence 1 — Organism
Curated By Autocuration

Target

T47D (CHEMBL614361)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and biological evaluation of D-ring fused 1,2,3-thiadiazole dehydroepiandrosterone derivatives as antitumor agents.
Cui HW, Peng S, Gu XZ, Chen H, He Y, Gao W, Lv F, Wang JH, Wang Y, Xie J, Liu MY, Yi Z, Qiu WW.
Eur J Med Chem (2016) 111 : 126 -137
PubMed 26866967 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 6.17 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL359744 DOXORUBICIN HYDROCHLORIDE 4.0 1 7.40
CHEMBL3770137 1 7.38
CHEMBL3770805 1 7.29
CHEMBL3769913 1 7.24
CHEMBL3771045 1 6.62
CHEMBL3770683 1 6.17
CHEMBL3770246 1 6.04
CHEMBL3769630 1 5.94
CHEMBL272195 EPIANDROSTERONE 1 5.91
CHEMBL3769728 1 5.87
CHEMBL3770372 1 5.66
CHEMBL3769515 1 5.65
CHEMBL90593 PRASTERONE 4.0 1 5.59
CHEMBL3770168 1 5.58
CHEMBL3771344 1 5.55
CHEMBL3770344 1 5.52
CHEMBL3771030 1 5.48

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL359744 DOXORUBICIN HYDROCHLORIDE IC50 = 40.0 nM 7.40
CHEMBL3770137 IC50 = 42.0 nM 7.38
CHEMBL3770805 IC50 = 51.0 nM 7.29
CHEMBL3769913 IC50 = 58.0 nM 7.24
CHEMBL3771045 IC50 = 240.0 nM 6.62
CHEMBL3770683 IC50 = 670.0 nM 6.17
CHEMBL3770246 IC50 = 920.0 nM 6.04
CHEMBL3769630 IC50 = 1150.0 nM 5.94
CHEMBL272195 EPIANDROSTERONE IC50 = 1230.0 nM 5.91
CHEMBL3769728 IC50 = 1360.0 nM 5.87
CHEMBL3770372 IC50 = 2170.0 nM 5.66
CHEMBL3769515 IC50 = 2250.0 nM 5.65
CHEMBL90593 PRASTERONE IC50 = 2550.0 nM 5.59
CHEMBL3770168 IC50 = 2660.0 nM 5.58
CHEMBL3771344 IC50 = 2830.0 nM 5.55
CHEMBL3770344 IC50 = 3040.0 nM 5.52
CHEMBL3771030 IC50 = 3280.0 nM 5.48