Assay Detail
ADMET
CHEMBL3776780
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Inhibition of CYP3A4 (unknown origin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.22 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3775473 | — | — | 1 | 6.44 |
| CHEMBL3775389 | — | — | 1 | 5.32 |
| CHEMBL3775476 | — | — | 1 | 5.26 |
| CHEMBL3775798 | — | — | 1 | 5.24 |
| CHEMBL3775370 | — | — | 1 | 5.17 |
| CHEMBL3774871 | — | — | 1 | 5.15 |
| CHEMBL3774852 | — | — | 1 | 4.58 |
| CHEMBL3775464 | — | — | 1 | 4.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3775473 | — | IC50 | = | 363.0 | nM | 6.44 |
| CHEMBL3775389 | — | IC50 | = | 4778.0 | nM | 5.32 |
| CHEMBL3775476 | — | IC50 | = | 5544.0 | nM | 5.26 |
| CHEMBL3775798 | — | IC50 | = | 5810.0 | nM | 5.24 |
| CHEMBL3775370 | — | IC50 | = | 6697.0 | nM | 5.17 |
| CHEMBL3774871 | — | IC50 | = | 7040.0 | nM | 5.15 |
| CHEMBL3774852 | — | IC50 | = | 26139.0 | nM | 4.58 |
| CHEMBL3775464 | — | IC50 | = | 25988.0 | nM | 4.58 |