Assay Detail
Binding
CHEMBL3779261
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Inhibition of ovine COX1 assessed as production of PGF2-alpha preincubated with compound followed by the addition of 5 uM arachidonic acid as substrate by enzyme immunoassay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 6.48 | 9.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3774784 | — | — | 1 | 9.54 |
| CHEMBL3774941 | — | — | 1 | 8.05 |
| CHEMBL3775510 | — | — | 1 | 8.00 |
| CHEMBL3774833 | — | — | 1 | 7.96 |
| CHEMBL3775041 | — | — | 1 | 7.92 |
| CHEMBL3775653 | — | — | 1 | 7.85 |
| CHEMBL3775104 | — | — | 1 | 7.70 |
| CHEMBL3774442 | — | — | 1 | 7.52 |
| CHEMBL3774686 | — | — | 1 | 7.27 |
| CHEMBL3775430 | — | — | 1 | 6.89 |
| CHEMBL563 | FLURBIPROFEN | 4.0 | 1 | 6.82 |
| CHEMBL3774467 | — | — | 1 | 6.82 |
| CHEMBL3775528 | — | — | 1 | 6.66 |
| CHEMBL3774439 | — | — | 1 | 6.58 |
| CHEMBL3774754 | — | — | 1 | 6.57 |
| CHEMBL3775979 | — | — | 1 | 6.43 |
| CHEMBL3774586 | — | — | 1 | 6.24 |
| CHEMBL3774541 | — | — | 1 | 6.22 |
| CHEMBL3775676 | — | — | 1 | 6.19 |
| CHEMBL3775954 | — | — | 1 | 6.14 |
| CHEMBL3775610 | — | — | 1 | 6.14 |
| CHEMBL3774873 | — | — | 1 | 6.00 |
| CHEMBL3775280 | — | — | 1 | 5.96 |
| CHEMBL3775392 | — | — | 1 | 5.89 |
| CHEMBL3774876 | — | — | 1 | 5.78 |
| CHEMBL3775770 | — | — | 1 | 5.68 |
| CHEMBL3774618 | — | — | 1 | 5.68 |
| CHEMBL3774805 | — | — | 1 | 5.43 |
| CHEMBL3774781 | — | — | 1 | 5.41 |
| CHEMBL3774706 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3774784 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL3774941 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3775510 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3774833 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3775041 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3775653 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3775104 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3774442 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3774686 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL3775430 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3774467 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL563 | FLURBIPROFEN | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3775528 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3774439 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3774754 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL3775979 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL3774586 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL3774541 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3775676 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL3775610 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL3775954 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL3774873 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL3775280 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3775392 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3774876 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL3775770 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3774618 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3774805 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL3774781 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL3774706 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3775699 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL3774572 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL3775973 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL3775462 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL3774867 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL3774999 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3774393 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3775360 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3775475 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL184238 | URB-597 | IC50 | > | 100000.0 | nM | - |