Assay Detail
Functional
CHEMBL3783450
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Cytotoxicity against human MV522 cells after 48 hrs by trypan blue exclusion assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV522 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Hydroxyurea derivatives of irofulven with improved antitumor efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.91 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118218 | IROFULVEN | 3.0 | 1 | 7.16 |
| CHEMBL3780084 | — | — | 1 | 6.89 |
| CHEMBL3781819 | LP-184 | 1.0 | 1 | 6.68 |
| CHEMBL467 | HYDROXYUREA | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118218 | IROFULVEN | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3780084 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3781819 | LP-184 | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL467 | HYDROXYUREA | IC50 | > | 650000.0 | nM | - |