Assay Detail
ADMET
CHEMBL3783451
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Cytotoxicity against human CHRF-288-11 cells after 48 hrs by trypan blue exclusion assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Hydroxyurea derivatives of irofulven with improved antitumor efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.77 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118218 | IROFULVEN | 3.0 | 1 | 6.54 |
| CHEMBL3780084 | — | — | 1 | 5.72 |
| CHEMBL3781819 | LP-184 | 1.0 | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118218 | IROFULVEN | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3780084 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3781819 | LP-184 | IC50 | = | 8800.0 | nM | 5.06 |