Assay Detail
Binding
CHEMBL3784069
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at Renilla luciferase/GFP2-tagged RXRalpha/Nurr1 (unknown origin) expressed in HEK293T cells by BRET2 assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha (CHEMBL3885613) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Chiral Dihydrobenzofuran Acids Show Potent Retinoid X Receptor-Nuclear Receptor Related 1 Protein Dimer Activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.53 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1023 | BEXAROTENE | 4.0 | 1 | 8.00 |
| CHEMBL3780763 | — | — | 1 | 7.90 |
| CHEMBL3781132 | — | — | 1 | 7.90 |
| CHEMBL3780806 | — | — | 1 | 6.30 |
| CHEMBL3781879 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1023 | BEXAROTENE | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3780763 | — | EC50 | = | 12.59 | nM | 7.90 |
| CHEMBL3781132 | — | EC50 | = | 12.59 | nM | 7.90 |
| CHEMBL3780806 | — | EC50 | = | 501.19 | nM | 6.30 |
| CHEMBL3781879 | — | EC50 | > | 3162.28 | nM | - |