Evidence Snapshot

Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha

CHEMBL3885613 PROTEIN COMPLEX Homo sapiens

Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:30:14Z

Source · ChEMBL 36 via Core Engine Freshness · Sep 14, 2026, 7:30 AM KST As of · Sep 13, 2026

ChEMBL ChEMBL 36 CHEMBL3885613

Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha as ChEMBL target CHEMBL3885613, mapped to UniProt P19793. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor

Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha

PROTEIN COMPLEX · Homo sapiens

As of 2026-09-13

ChEMBL target ID

CHEMBL3885613

Primary anchor for compounds, assays, approvals, and exports

ChEMBL 36 via Core Engine As of 2026-09-13

www.ebi.ac.uk

UniProt accession

P19793

Retinoic acid receptor RXR-alpha

UniProt accession via ChEMBL component mapping As of 2026-09-13

www.uniprot.org

Disease evidence contract

Open Targets-ready proxy

ChEMBL drug mechanism + indication proxy

ChEMBL drug mechanism + indication proxy As of 2026-09-13

www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha matters

As of 2026-09-13

Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha is reviewed as Retinoic acid receptor RXR-alpha (UniProt P19793); the current evidence base includes 2 approved drugs, 8 compounds, and 6 assays, with lead potency reaching pChEMBL 9.1.

Protein context

Retinoic acid receptor RXR-alpha

Retinoic acid receptor RXR-alpha Sequence length is 462 aa.

Review this target as Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha, mapped to UniProt P19793. ChEMBL maps the protein component as Retinoic acid receptor RXR-alpha. Sequence length is 462 aa.

Protein source · UniProt accession via ChEMBL component mapping

UniProt P19793 Protein

Disease context

Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record

Activity base

Portfolio and assay base

ChEMBL currently tracks 2 approved drugs, 8 compounds, and 6 assays for this target. The dominant activity type is EC50. CHEMBL5266566 is the current potency anchor at pChEMBL 9.1.

Use CHEMBL5266566 as the tractability anchor when discussing potency (pChEMBL 9.1).

Activity source · ChEMBL 36 via Core Engine

2 approved pChEMBL 9.1

Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?

Review-ready Target Rationale

One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha matters before drilling into raw source blocks.

Jump to Review Rationale

Need stable protein naming or accession mapping?

UniProt Target Context

UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P19793, not just the summarized rationale.

Open Protein Context

Need disease fit or evidence level for program framing?

Disease Relevance & Evidence Level

ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

Total Compounds

Total Assays

Approved Drugs

EC50: 9.0

Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Compound	pChEMBL	Type	Phase
No preferred name CHEMBL5266566	9.1	EC50	—
No preferred name CHEMBL1023	8.3	EC50	Approved
No preferred name CHEMBL3781132	7.9	EC50	—
No preferred name CHEMBL3780763	7.9	EC50	—
No preferred name CHEMBL3780806	6.3	EC50	—