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Assay Detail

CHEMBL3784264

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 20mins before the addition of substrate by Ellman's method
53
Total Activities
50
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Equus caballus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cholinesterase (CHEMBL5763)
Type SINGLE PROTEIN
Organism Equus caballus

Publication

Converting maslinic acid into an effective inhibitor of acylcholinesterases.
Schwarz S, Loesche A, Lucas SD, Sommerwerk S, Serbian I, Siewert B, Pianowski E, Csuk R.
Eur J Med Chem (2015) 103 : 438 -445
PubMed 26383128 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 50 4.78 5.03
IC50 3 4.60 4.78

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1555 GALANTAMINE HYDROBROMIDE 4.0 1 5.03
CHEMBL3780432 2 4.91
CHEMBL482673 AUGUSTIC ACID 2 4.78
CHEMBL1914930 2 4.74
CHEMBL3781417 1 -
CHEMBL3086597 1 -
CHEMBL3086596 1 -
CHEMBL3780423 1 -
CHEMBL3780395 1 -
CHEMBL3781042 1 -
CHEMBL3779951 1 -
CHEMBL3781066 1 -
CHEMBL3781136 1 -
CHEMBL3780430 1 -
CHEMBL3086607 1 -
CHEMBL201515 MASLINIC ACID 1 -
CHEMBL202346 MASLINIC ACID METHYL ESTER 1 -
CHEMBL3781928 1 -
CHEMBL3781667 1 -
CHEMBL3781640 1 -
CHEMBL3086616 1 -
CHEMBL1914929 1 -
CHEMBL3325867 1 -
CHEMBL3325866 1 -
CHEMBL3781812 1 -
CHEMBL508614 1 -
CHEMBL3779955 1 -
CHEMBL4299322 1 -
CHEMBL3781995 1 -
CHEMBL3086595 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1555 GALANTAMINE HYDROBROMIDE Ki = 9370.0 nM 5.03
CHEMBL3780432 Ki = 12430.0 nM 4.91
CHEMBL482673 AUGUSTIC ACID IC50 = 16560.0 nM 4.78
CHEMBL1914930 Ki = 18110.0 nM 4.74
CHEMBL3780432 IC50 = 28200.0 nM 4.55
CHEMBL1914930 IC50 = 34150.0 nM 4.47
CHEMBL482673 AUGUSTIC ACID Ki = 35640.0 nM 4.45
CHEMBL3086605 Ki > 20000.0 nM -
CHEMBL202346 MASLINIC ACID METHYL ESTER Ki > 50000.0 nM -
CHEMBL3086604 Ki > 80000.0 nM -
CHEMBL3086603 Ki > 6000.0 nM -
CHEMBL3086602 Ki > 10000.0 nM -
CHEMBL3086601 Ki > 10000.0 nM -
CHEMBL3086600 Ki > 30000.0 nM -
CHEMBL3086599 Ki > 6000.0 nM -
CHEMBL204906 Ki > 100000.0 nM -
CHEMBL3086597 Ki > 14000.0 nM -
CHEMBL201820 BENZYL MASLINATE Ki > 14000.0 nM -
CHEMBL3086607 Ki > 10000.0 nM -
CHEMBL4299322 Ki > 4000.0 nM -
CHEMBL3086609 Ki > 10000.0 nM -
CHEMBL3086610 Ki > 80000.0 nM -
CHEMBL3086611 Ki > 6000.0 nM -
CHEMBL372331 Ki > 10000.0 nM -
CHEMBL3086612 Ki > 6000.0 nM -
CHEMBL3086613 Ki - -
CHEMBL3086614 Ki - -
CHEMBL3086615 Ki > 14000.0 nM -
CHEMBL3086595 Ki > 20000.0 nM -
CHEMBL3781928 Ki > 20000.0 nM -
CHEMBL3781995 Ki > 6000.0 nM -
CHEMBL3779955 Ki > 100000.0 nM -
CHEMBL508614 Ki > 10000.0 nM -
CHEMBL3781812 Ki > 20000.0 nM -
CHEMBL3325866 Ki > 40000.0 nM -
CHEMBL3325867 Ki > 20000.0 nM -
CHEMBL1914929 Ki > 20000.0 nM -
CHEMBL3086616 Ki > 20000.0 nM -
CHEMBL3781640 Ki > 14000.0 nM -
CHEMBL201515 MASLINIC ACID Ki > 100000.0 nM -
CHEMBL3781417 Ki > 6000.0 nM -
CHEMBL3086596 Ki > 20000.0 nM -
CHEMBL3780423 Ki > 14000.0 nM -
CHEMBL3780395 Ki > 10000.0 nM -
CHEMBL3781042 Ki > 30000.0 nM -
CHEMBL3779951 Ki > 20000.0 nM -
CHEMBL3781066 Ki > 10000.0 nM -
CHEMBL3781136 Ki > 6000.0 nM -
CHEMBL3780430 Ki > 6000.0 nM -
CHEMBL3086608 Ki > 20000.0 nM -